rasfonin

07/13/2022 - "Inhibition of RIP1 either chemically or genetically reversed the inhibition of rasfonin on autophagy, whereas knockdown of Grb2 markedly reduced rasfonin-induced necrosis. "
01/01/2016 - "Flow cytometry analysis revealed NAC was able to reduce rasfonin-dependent apoptosis and necrosis. "
07/13/2022 - "In the present study, we found that rasfonin, a fungal natural product and an activator of necroptosis, enhanced Grb2 binding to receptor-interacting serine/threonine kinase 1 (RIP1), which plays a critical role in regulating programmed necrosis. "

12/01/2020 - "In present study, we found that rasfonin, which isolated from Talaromyces sp. 3656-A1 and was a fungal natural product, activated both caspase-dependent apoptosis and autophagy in ACHN, a renal carcinoma cell line. "
12/01/2020 - "Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells."

06/24/2023 - "Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer."
05/22/2014 - "Tumor weight was ultimately decreased after 20 days of treatment of rasfonin. "
05/22/2014 - "The in vivo experiments also revealed that rasfonin (30 mg/kg) delayed the growth of xenograft tumors originating from Panc-1 cells. "
06/24/2023 - "In the course of strain characterisation work we found that this strain is able to naturally produce high amounts of rasfonin, a polyketide inducing autophagy, apoptosis, necroptosis in human cell lines and showing anti-tumor activity in KRAS-dependent cancer cells. "
05/22/2014 - "Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice."

01/01/2016 - "Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line."
12/03/2015 - "Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells."

04/18/2019 - "Rasfonin induced autophagy and activated caspase-dependent apoptosis in 143B cells concurring with suppressing the proliferation and migration of the cells; these results provide an experimental basis for rasfonin as a potential therapeutic agent for osteosarcoma."
04/18/2019 - "To investigate the effects of rasfonin, a fungal secondary metabolite, on the proliferation and migration of osteosarcoma 143B cells. "
04/18/2019 - "[Rasfonin inhibits proliferation and migration of osteosarcoma 143B cells]."