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methylene-lactone

structure in first source

Also Known As:

alpha-exo-methylene-gamma-lactone

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - methylene-lactone: 6

Experts

1.	Altobelli, Chad R: 1 article (01/2019)
2.	Berdan, Charles A: 1 article (01/2019)
3.	Demeulenaere, Sasha G: 1 article (01/2019)
4.	Ho, Raymond: 1 article (01/2019)
5.	Hu, Xirui: 1 article (01/2019)
6.	Huffman, Tucker R: 1 article (01/2019)
7.	Lehtola, Haley S: 1 article (01/2019)
8.	Maimone, Thomas J: 1 article (01/2019)
9.	Nomura, Daniel K: 1 article (01/2019)
10.	Olzmann, James A: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1977 - "Synthesis of mono- and bifunctional alpha-methylene lactone systems as potential tumor inhibitors." 04/17/1970 - "Reactions of alpha methylene lactone tumor inhibitors with model biological nucelophiles." 06/20/2011 - "In this study, we synthesized six structurally related xanthanolides containing exo-methylene lactone moieties, including (--)-xanthatin and (+)-8-epi-xanthatin, and examined the effects of these chemically defined substances on the highly aggressive and farnesyltransferase inhibitor (FTI)-resistant MDA-MB-231 cancer cell line. " 04/17/1970 - "Inhibition of phosphofructokinase by quinone methide and alpha-methylene lactone tumor inhibitors."
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/1977 - "Synthetic nono- and bifunctional alpha-methylene lactone derivatives including deoxyvernolepin and kihydrodeoxyvernolepin were tested as inhibitors of the growth of CCRF-CEM human lymphoblastic leukemia cells in culture. "
3.	Allergic Contact Dermatitis 11/01/1987 - "Stereospecificity in allergic contact dermatitis to simple substituted methylene lactone derivatives."
4.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "We find that parthenolide, as well as other related exocyclic methylene lactone-containing sesquiterpenes, covalently modify cysteine 427 of focal adhesion kinase 1 (FAK1), leading to impairment of FAK1-dependent signaling pathways and breast cancer cell proliferation, survival, and motility. "

Related Drugs and Biologics

1.	Farnesyltranstransferase (Farnesyltransferase)
2.	xanthatin
3.	Focal Adhesion Kinase 1
4.	Phosphofructokinases
5.	Sesquiterpenes
6.	Cysteine (L-Cysteine)
7.	quinone methide
8.	deoxyvernolepin
9.	parthenolide