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4- (2'- methoxyphenyl)- 1- (2'- (N- 2'- pyridinyl)- p- (18F)fluorobenzamido )ethylpiperazine

suitable for 5-HT1A receptor imaging in humans

Also Known As:

(18F)MPPF

Networked: 8 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 4-(2'-methoxyphenyl)-1-(2'-(N-2'-pyridinyl)-p-(18F)fluorobenzamido )ethylpiperazine: 8
  - Piperazines: 26
    - 4-(2'-methoxyphenyl)-1-(2'-(N-2'-pyridinyl)-p-(18F)fluorobenzamido )ethylpiperazine: 8

Experts

1.	Koska, Ines: 3 articles (01/2021 - 10/2018)
2.	Potschka, Heidrun: 3 articles (01/2021 - 10/2018)
3.	Costes, Nicolas: 3 articles (12/2008 - 04/2004)
4.	Seiffert, Isabel: 2 articles (01/2021 - 10/2018)
5.	Bartenstein, Peter: 2 articles (09/2020 - 10/2018)
6.	Brendel, Matthias: 2 articles (09/2020 - 10/2018)
7.	Gildehaus, Franz Josef: 2 articles (09/2020 - 10/2018)
8.	Waldron, Ann-Marie: 2 articles (09/2020 - 10/2018)
9.	Ziegler, Sibylle: 2 articles (09/2020 - 10/2018)
10.	van Dijk, R Maarten: 2 articles (09/2020 - 10/2018)

Related Diseases

1.	Temporal Lobe Epilepsy 10/01/2008 - "Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study." 04/01/2004 - "5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study."
2.	Seizures (Absence Seizure) 10/01/2018 - "In addition, an increase in septal [18F]MPPF binding was observed in rats with spontaneous recurrent seizures. " 01/01/2021 - "Previous µPET studies revealed increased binding of the 5-HT1A receptor ligand [18F]MPPF in two rat models with spontaneous recurrent seizures. "
3.	Narcolepsy 04/01/2006 - "14 subjects with narcolepsy cataplexy underwent [18F]MPPF PET scans in wakefulness and in sleep. " 04/01/2006 - "Increased serotonin receptor availability in human sleep: evidence from an [18F]MPPF PET study in narcolepsy."
4.	Epilepsy (Aura) 10/01/2018 - "Moreover, thalamic [18F]FDG and septal [18F]MPPF data exhibited a correlation with brain-derived neurotrophic factor (BDNF) serum concentrations, which were lowered in rats with epilepsy. " 10/01/2018 - "In the current study we investigated the potential of [18F]fluoro-2-deoxy-d-glucose ([18F]FDG) and 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine ([18F]MPPF) as imaging correlates of neurobehavioral comorbidities in the pilocarpine rat model of epilepsy. "
5.	Anorexia Nervosa 12/01/2008 - "Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan study."

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Serotonin Receptors
3.	Pilocarpine (Ocusert)
4.	Ligands
5.	Deoxyglucose (2 Deoxy D glucose)
6.	Brain-Derived Neurotrophic Factor (BDNF)