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glutamyl-prolyl-tRNA synthetase

Also Known As:

EPRS enzyme

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        glutamyl-prolyl-tRNA synthetase: 11

Experts

1.	Kim, Sunghoon: 2 articles (01/2018 - 11/2016)
2.	Chen, Xiaobing: 1 article (01/2021)
3.	Dong, Zigang: 1 article (01/2021)
4.	Fredimoses, Mangaladoss: 1 article (01/2021)
5.	Kim, Dong Joon: 1 article (01/2021)
6.	Li, Xiang: 1 article (01/2021)
7.	Liu, Hui: 1 article (01/2021)
8.	Liu, Kangdong: 1 article (01/2021)
9.	Liu, Tingting: 1 article (01/2021)
10.	Niu, Peijia: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/25/2016 - "Several studies have suggested a role for the glutamyl prolyl tRNA synthetase (EPRS) in breast cancers, although none has identified any underlying mechanism about how EPRS contributes to carcinogenesis. " 05/03/2023 - "Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is an aminoacyl-tRNA synthase involved in the pathology of cancer and other diseases. " 01/01/2021 - "Glutamyl-prolyl-tRNA synthetase (EPRS/GluRS) is primarily part of the multi-synthetase complex that may play a key role in cancer development. "
2.	Carcinogenesis 10/25/2016 - "Several studies have suggested a role for the glutamyl prolyl tRNA synthetase (EPRS) in breast cancers, although none has identified any underlying mechanism about how EPRS contributes to carcinogenesis. "
3.	Fibrosis (Cirrhosis) 01/01/2018 - "Glutamyl-prolyl-tRNA-synthetase (EPRS) has been identified as a target for anti-fibrosis therapy, but the link between EPRS and TGFβ1-mediated IPF pathogenesis remains unknown. " 01/01/2023 - "Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is known to associated with fibrosis through its catalytic activity to produce prolyl-tRNA. " 01/01/2020 - "To investigate the role of a bifunctional ARS (aminoacyl-tRNA synthetase), EPRS (glutamyl-prolyl-tRNA synthetase) in translational control of cardiac fibrosis. " 01/01/2020 - "Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis."
4.	Idiopathic Pulmonary Fibrosis 01/01/2018 - "Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis."
5.	Virus Diseases (Viral Diseases) 11/01/2016 - "Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. "

Related Drugs and Biologics

1.	Transfer RNA (tRNA)
2.	Proteins (Proteins, Gene)
3.	Extracellular Matrix Proteins
4.	Proline (L-Proline)
5.	Ligases (Synthetase)
6.	Arginine-tRNA Ligase
7.	Antiviral Agents (Antivirals)
8.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)

Related Therapies and Procedures

1.	Therapeutics