clomeleon

a fluorescent recombinant fusion protein which, when expressed intracellularly, enables ratiometric intracellular chloride ion level measurements by fluorescence spectrophotometry

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Augustine, George J: 2 articles (09/2010 - 02/2006)
2.	Feng, Guoping: 2 articles (09/2010 - 02/2006)
3.	Kuner, Thomas: 2 articles (09/2010 - 02/2006)
4.	Bacskai, Brian J: 1 article (09/2010)
5.	Dzhala, Volodymyr I: 1 article (09/2010)
6.	Glykys, Joseph C: 1 article (09/2010)
7.	Kahle, Kristopher T: 1 article (09/2010)
8.	Kuchibhotla, Kishore V: 1 article (09/2010)
9.	Staley, Kevin J: 1 article (09/2010)
10.	Swiercz, Waldemar B: 1 article (09/2010)

Related Diseases

1.	Seizures (Absence Seizure) 09/01/2010 - "We now report that, in intact hippocampi prepared from neonatal rats and transgenic mice expressing Clomeleon, recurrent seizures progressively increase the intracellular chloride concentration ([Cl(-)](i)) assayed by Clomeleon imaging and invert the net effect of GABA(A) receptor activation from inhibition to excitation assayed by the frequency of action potentials and intracellular Ca(2+) transients. "
2.	Ischemia 02/01/2006 - "To directly measure changes in intracellular Cl- concentration ([Cl-]i) during and after ischemia, we used Clomeleon, a novel ratiometric optical indicator for Cl-. " 02/01/2006 - "Hippocampal slices from adult transgenic mice expressing Clomeleon in hippocampal neurons were subjected to 8 min of oxygen-glucose deprivation (OGD) (an in vitro model for ischemia) and reoxygenated in the presence of glucose. "

Related Drugs and Biologics

1.	GABA-A Receptors (GABA(A) Receptor)
2.	Oxygen (Dioxygen)
3.	Indicators and Reagents (Reagents)
4.	Glucose (Dextrose)
5.	Chlorides