calpain 10

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal tranduction; genetic variation in CAPN10 is associated with type 2 diabetes mellitus

Also Known As:

Networked: 75 relevant articles (0 outcomes, 15 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Schnellmann, Rick G: 7 articles (10/2012 - 12/2006)
2.	Smith, Matthew A: 3 articles (10/2012 - 07/2012)
3.	Covington, Marisa D: 3 articles (07/2012 - 02/2008)
4.	Ramírez-Lorca, Reposo: 3 articles (01/2011 - 01/2007)
5.	Ruiz, Agustín: 3 articles (01/2011 - 01/2007)
6.	Sieradzki, Jacek: 3 articles (04/2008 - 05/2002)
7.	Cox, Nancy J: 3 articles (07/2005 - 04/2002)
8.	Beeson, Craig C: 2 articles (08/2012 - 01/2009)
9.	Arrington, David D: 2 articles (01/2009 - 12/2006)
10.	González, Alejandro: 2 articles (08/2008 - 01/2007)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 03/01/2009 - "[Study of association of the SNP19 polymorphism of calpain 10 gene with type 2 diabetes in ethnic sub-groups of the Tunisian population: gene-environment interaction]." 03/31/2005 - "Because of recent studies showing linkage of type 2 diabetes with the calpain 10 gene, we investigated the ability of calpains to regulate GLUT4 expression in 3T3-L1 adipocytes. " 05/01/2002 - "This study supports the paradigm that specific haplotype combinations of calpain 10 variants increase risk of both IFG/IGT and type 2 diabetes. " 10/01/2019 - "GSTT1, Calpain 10 SNP 19 and indices of glycaemia in type 2 diabetes." 05/01/2019 - "Calpain 10 plays a role in insulin secretion, action and susceptibility to type 2 diabetes. "
2.	Insulin Resistance 06/01/2002 - "In some populations, Calpain 10 gene polymorphisms increase susceptibility to diabetes or insulin resistance. " 02/28/2018 - "GDM has been associated with insulin resistance and dysfunction of pancreatic beta cells, so the GDM candidate genes are those that encode proteins modulating the function and secretion of insulin, such as that for calpain 10 (CAPN10). " 05/01/2005 - "These studies confirm calpain 10 expression in cultured human muscle cells and support a role for calpains in insulin-stimulated glucose uptake in human skeletal muscle cells that may be relevant to the pathogenesis of the peripheral insulin resistance in type 2 diabetes." 01/01/2012 - "The purpose of this review is to present some evidence of studies that have already demonstrated the significance of gene-nutrient interactions (adiponectin gene, Calpain-10, glucokinase regulatory protein, transcription factor 7-like 2, leptin receptor, scavenger receptor class B type I etc.) that influence insulin resistance in subjects with metabolic syndrome."
3.	Mitochondrial Diseases (Mitochondrial Disease) 07/15/2012 - "These results provide evidence that diabetes-induced renal mitochondrial dysfunction and renal injury may directly result from the loss of renal calpain 10." 01/08/2009 - "Calpain 10 has been localized to the mitochondria and is a key mediator of Ca(2+) induced mitochondrial dysfunction. " 07/15/2012 - "Loss of calpain 10 causes mitochondrial dysfunction during chronic hyperglycemia." 10/01/2012 - "Calpain 10 cleaves electron transport chain proteins, causing decreased mitochondrial respiration and excessive activation, or inhibition of calpain 10 activity induces mitochondrial dysfunction and apoptosis. " 08/17/2012 - "Calpain 10 is a ubiquitously expressed mitochondrial and cytosolic Ca(2+)-regulated cysteine protease in which overexpression or knockdown leads to mitochondrial dysfunction and cell death. "
4.	Gestational Diabetes (Gestational Diabetes Mellitus) 07/11/2019 - "BACKGROUND This study aimed to investigate the association between the rs2975760 and rs3792267 single nucleotide polymorphisms (SNPs) of the calpain 10 (CAPN10) gene and gestational diabetes mellitus. " 07/11/2019 - "The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus." 02/28/2018 - "Association analysis of calpain 10 gene variants/haplotypes with gestational diabetes mellitus among Mexican women." 12/01/2014 - "Investigation of Calpain 10 (rs2975760) gene polymorphism in Asian Indians with Gestational Diabetes Mellitus."
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/2009 - "This study was designed in order to examine the relationship between Calpain 10 [single-nucleotide polymorphism (SNP) 19,43,44,63] gene polymorphisms and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS). " 01/01/2009 - "Calpain 10 gene single-nucleotide 44 polymorphism may have an influence on clinical and metabolic features in patients with polycystic ovary syndrome." 01/16/2007 - "Cysteine protease Calpain 10 (CAPN10) has been associated with T2DM, hypertension, hypercholesterolemia, increased body mass index (BMI) and polycystic ovary syndrome (PCOS), a reproductive disorder of women in which isunlin resistance seems to play a pathogenic role. "

Related Drugs and Biologics

1.	Calpain
2.	Glucose (Dextrose)
3.	Insulin (Novolin)
4.	Peptide Hydrolases (Proteases)
5.	m-calpain
6.	Leptin Receptors
7.	Adiponectin
8.	T Cell Transcription Factor 1
9.	Facilitative Glucose Transport Proteins (Glucose Transporter)
10.	Scavenger Receptors (Scavenger Receptor)