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odoroside

obtained from Nerium oleander extract; structure in first source

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        odoroside: 5

Experts

1.	Chen, Yan-Yan: 1 article (01/2019)
2.	Deng, Chun-Miao: 1 article (01/2019)
3.	He, Qing-Yu: 1 article (01/2019)
4.	Jiang, Miao-Miao: 1 article (01/2019)
5.	Sun, Zheng-Hua: 1 article (01/2019)
6.	Wen, Shi-Yuan: 1 article (01/2019)
7.	Yin, Xing-Feng: 1 article (01/2019)
8.	Jin, Hana: 1 article (10/2018)
9.	Kim, Hye Jung: 1 article (10/2018)
10.	Ko, Young Shin: 1 article (10/2018)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/26/2018 - "Therefore, in this study, we aimed to investigate the anticancer effects of oleandrin and odoroside A and their associated mechanisms in highly metastatic MDA-MB-231 breast cancer cells and radiotherapy-resistant (RT-R) MDA-MB-231 cells. "
2.	Neoplasms (Cancer) 05/01/2012 - "Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines." 02/16/2023 - "Remarkably, the cellular responsiveness of odoroside H and neritaloside was not correlated with all other classical drug resistance mechanisms, i.e., ATP-binding cassette transporters (ABCB1, ABCB5, ABCC1, ABCG2), oncogenes (EGFR, RAS), tumor suppressors (TP53, WT1), and others (GSTP1, HSP90, proliferation rate), in 59 tumor cell lines of the National Cancer Institute (NCI, USA), indicating that Breastin may indeed bypass drug resistance. " 10/26/2018 - "The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from Nerium oleander, have been found to have antitumor effects on various tumors at low doses. " 02/16/2023 - "Proteome profiling of 3171 proteins in the NCI panel revealed protein subsets whose expression significantly correlated with cellular responsiveness to odoroside H and neritaloside, indicating that protein expression profiles can be identified to predict the sensitivity or resistance of tumor cells to Breastin constituents. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Proteomic Analysis Reveals that Odoroside A Triggers G2/M Arrest and Apoptosis in Colorectal Carcinoma Through ROS-p53 Pathway."
4.	Carcinoma (Carcinomatosis) 11/01/2009 - "Odoroside A [3beta-O-(beta-D-diginosyl)-14-hydroxy-5beta,14beta-card-20(22)-enolide] was found to inhibit the cell-surface expression of ICAM-1 induced by TNF-alpha and IL-1 at comparable concentrations in human lung carcinoma A549 cells. "

Related Drugs and Biologics

1.	oleandrin
2.	Proteome
3.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
4.	ATP-Binding Cassette Transporters (ABC Transporters)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Proteins (Proteins, Gene)
7.	Interleukin-1 (Interleukin 1)
8.	Cardiac Glycosides
9.	neritaloside

Related Therapies and Procedures

1.	Radiotherapy