Zidovudine FDA Link Generic

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Also Known As:

Retrovir; Azidothymidine; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; AZT Antiviral; AZT, Antiviral; BW A509U; BWA-509U; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; Antiviral AZT; BWA 509U; BWA509U; AZT (Antiviral); Thymidine, 3'-azido-3'-deoxy-

Pharmalogical Action Categories:

Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        Zidovudine: 3074
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - Zidovudine: 3074
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - Zidovudine: 3074
    - Dideoxynucleosides: 27
      - Zidovudine: 3074

KNI 1039

Bio-Agent Context: Research Results