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4-hydroxy-4-(indol-3-ylmethyl)glutamic acid

structure in first source

Also Known As:

(2S,4S)-4-hydroxy-4-(indol-3-ylmethyl)glutamic acid; 2-amino-4-carboxy-4-hydroxy-5-(3-indolyl)pentanoic acid; monatin

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 4-hydroxy-4-(indol-3-ylmethyl)glutamic acid: 3
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Brathwaite, Witty A: 2 articles (05/2016 - 06/2014)
2.	Crincoli, Christine M: 2 articles (05/2016 - 06/2014)
3.	Eapen, Alex K: 1 article (05/2016)
4.	Nikiforov, Andrey I: 1 article (05/2016)
5.	Remick, Amera K: 1 article (05/2016)
6.	Rihner, Marisa O: 1 article (05/2016)
7.	Casterton, Phillip L: 1 article (06/2014)
8.	Brathwaite, W A: 1 article (12/2011)
9.	Eapen, A K: 1 article (12/2011)
10.	Hlywka, J: 1 article (12/2011)

Related Diseases

1.	Body Weight (Weight, Body) 12/01/2011 - "Based on the results of this study, and conservatively assuming the body weight observations at the MTD to be indicative of an adverse effect, the dietary no-observed-adverse-effect level (NOAEL) of R,R-monatin salt for 90 days was 20,000 ppm in female rats (approximately 1544 mg/kg bw/day) and 35,000 ppm in male rats (approximately 2368 mg/kg bw/day)."
2.	Hyperostosis 05/01/2016 - "Effects of long-term R,R-monatin ingestion by rats were predominantly focused on the urinary system (i.e., clinical pathology alterations indicative of electrolyte and pH imbalances, increased incidence of renal calculi, mineralization and bone hyperostosis, and increased severity of chronic progressive nephropathy). "
3.	Lymphoma (Lymphomas) 06/01/2014 - "Arruva, the R,R-isomer of monatin (sodium/potassium 2R,4R-2-amino-4-carboxy-4-hydroxy-5-(3-indolyl) pentanoate), an intense sweetener originally identified in root bark of the South African shrub Schlerochitin ilicifolius, was examined for its mutagenic and genotoxic potential via bacterial reverse mutation, mouse lymphoma and in vivo mouse micronucleus assays, all accomplished in the presence and absence of S9 metabolic activation. "
4.	Kidney Calculi (Kidney Stone) 05/01/2016 - "Effects of long-term R,R-monatin ingestion by rats were predominantly focused on the urinary system (i.e., clinical pathology alterations indicative of electrolyte and pH imbalances, increased incidence of renal calculi, mineralization and bone hyperostosis, and increased severity of chronic progressive nephropathy). "

Related Drugs and Biologics

1.	Salts
2.	Valerates
3.	Sweetening Agents (Sweeteners)
4.	Sodium
5.	Potassium
6.	Electrolytes