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Co 2-6749

structure in first source

Also Known As:

3,21-dihydroxy-3-trifluoromethyl-19-nor-5beta-pregnan-20-one; Co-2-6749; GMA 839; GMA-839; WAY 141839; WAY-141839

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnanolone: 560
        Co 2-6749: 1

Experts

1.	Barrett, J E: 1 article (10/2000)
2.	Belluzzi, J D: 1 article (10/2000)
3.	Carter, R B: 1 article (10/2000)
4.	Hawkinson, J E: 1 article (10/2000)
5.	Lan, N C: 1 article (10/2000)
6.	Rosenzweig-Lipson, S: 1 article (10/2000)
7.	Stein, L: 1 article (10/2000)
8.	Vanover, K E: 1 article (10/2000)
9.	Wood, P L: 1 article (10/2000)

Related Diseases

1.

Ataxia (Dyssynergia)

10/01/2000 - "Co 2-6749 caused a dose-related increase in punished responding with a minimum effective dose of 1.6 mg/kg, p.o., a wide therapeutic index relative to a decrease in unpunished responding and relative to ataxia, and no tolerance. "
10/01/2000 - "With robust anxiolytic-like activity across species, a large separation between anxiolytic-like effects and sedation/ataxia, a minimal interaction with ethanol, a lack of tolerance, and apparent oral bioavailability, Co 2-6749 makes an ideal candidate for development as a novel anxiolytic drug."

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	Ethanol (Ethyl Alcohol)