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YM 976

a phosphodiesterase type 4 inhibitor; structure in first source

Also Known As:

4-(3-chlorophenyl)-1,7-diethylpyrido(2,3-d)pyrimidin-2(1H)-one; YM-976; YM976

Networked: 12 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - YM 976: 12
  - Pyridines: 88
    - YM 976: 12

Experts

1.	Aoki, M: 3 articles (04/2001 - 10/2000)
2.	Yamada, T: 3 articles (04/2001 - 10/2000)
3.	Abou Saleh, Lina: 2 articles (10/2020 - 01/2020)
4.	Aragon, Ileana V: 2 articles (10/2020 - 01/2020)
5.	Boyd, Abigail: 2 articles (10/2020 - 01/2020)
6.	Koloteva, Anna: 2 articles (10/2020 - 01/2020)
7.	McDonough, Will: 2 articles (10/2020 - 01/2020)
8.	Rich, Justin: 2 articles (10/2020 - 01/2020)
9.	Richter, Wito: 2 articles (10/2020 - 01/2020)
10.	Kobayashi, M: 2 articles (04/2001 - 10/2000)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2022 - "Mechanical hypersensitivity, evaluated using von Frey filaments, was relieved by sustained treatment with the non-selective PDEi theophylline and ibudilast (AV-411), with PDE4i rolipram, etazolate and YM-976, and with PDE5i sildenafil, zaprinast and MY-5445, but not by treatments with PDE1i vinpocetine, PDE2i EHNA or PDE3i milrinone. "
2.	Inflammation (Inflammations) 01/01/2023 - "Considering that accumulation of lipids in adipose tissue is accompanied by inflammation, we investigated whether YM976 affects adipocyte differentiation. " 01/01/2016 - "The findings indicate that PDE4 inhibition by YM976 exerts antitussive and anti-inflammatory effects in guinea pigs with ovalbumin-induced eosinophilic inflammation." 01/01/2016 - "The aim of this study was to evaluate the effects of a selective PDE4 inhibitor, YM976, on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity to histamine, and on inflammatory mediators in ovalbumin-sensitized guinea pigs, with experimentally induced eosinophil inflammation. "
3.	Cough 01/01/2016 - "The YM976 suppressed the number of coughs, the airway reactivity in tracheal tissue strips, and the IL-4 level. " 01/01/2016 - "Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs." 01/01/2016 - "The aim of this study was to evaluate the effects of a selective PDE4 inhibitor, YM976, on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity to histamine, and on inflammatory mediators in ovalbumin-sensitized guinea pigs, with experimentally induced eosinophil inflammation. "
4.	Bronchial Spasm 04/01/2001 - "In vivo studies indicated that the inhibitory effect of YM976 on LTD(4)-induced bronchospasm was marginal even at 30 mg/kg p.o., although rolipram significantly inhibited the bronchospasm at the same dose. "
5.	Vomiting 10/01/2000 - "YM976 produced no emesis up to 10 mg/kg, whereas rolipram and RP73401 induced emesis at oral doses of 3 mg/kg. To evidence the dissociation of anti-inflammatory activity from emesis, the anti-inflammatory effect of YM976 was examined in ferrets. " 12/01/2000 - "We compared the anti-inflammatory activity of YM976 with its emetic activity in ferrets, in which it dose dependently suppressed eosinophil infiltration at an ED(50) value of 1.2 mg/kg, but induced no emesis at 10 mg/kg. This suggested that the compound exhibits a considerable dissociation between its anti-inflammatory and emetic effects. " 07/10/2006 - "In contrast to YM976, YM-393059 did not shorten the duration of alpha2-adrenoceptor agonist-induced sleep in mice, which is a model for the assessment of the typical side effects caused by PDE4 inhibitors, nausea and emesis. "

Related Drugs and Biologics

1.	Rolipram
2.	Milrinone (Primacor)
3.	Theophylline (Theon)
4.	Etazolate
5.	Sildenafil Citrate (Viagra)
6.	MY 5445
7.	ibudilast
8.	vinpocetine
9.	zaprinast
10.	9-(2-hydroxy-3-nonyl)adenine (EHNA)