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angiotensin converting enzyme 2

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a homologue of angiotensin-converting enzyme (ACE), hydrolyzes carboxy-terminal leucine from angiotensin I to form angiotensin 1-9; 42% identical to angiotensin-converting enzyme in its catalytic domain; a target of SARS Virus

Also Known As:

ACE-related carboxypeptidase; ACE2 enzyme; ACE2 protein, human; ACEH protein, human; Ace2 protein, mouse; Ace2 protein, rat; Angiotensin-converting enzyme-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, human; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mouse; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, rat; angiotensin converting enzyme 2, human

Networked: 278 relevant articles (6 outcomes, 37 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Penninger, Josef M: 22 articles (01/2015 - 06/2002)
2.	Raizada, Mohan K: 21 articles (11/2015 - 12/2004)
3.	Katovich, Michael J: 16 articles (12/2014 - 05/2005)
4.	Oudit, Gavin Y: 13 articles (01/2015 - 06/2002)
5.	Shenoy, Vinayak: 11 articles (12/2014 - 02/2007)
6.	Ferrario, Carlos M: 8 articles (03/2014 - 06/2002)
7.	Burrell, Louise M: 8 articles (09/2013 - 03/2003)
8.	Ferreira, Anderson J: 8 articles (06/2013 - 05/2008)
9.	Kuba, Keiji: 7 articles (01/2015 - 08/2005)
10.	Schuster, Manfred: 7 articles (09/2012 - 09/2009)

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome) 03/15/2013 - "Angiotensin-converting enzyme 2 activation for treatment of pulmonary hypertension." 02/01/2010 - "Animals treated with angiotensin-converting enzyme 2 maintained significantly higher PaO2 than the control group, and pulmonary hypertension was less pronounced. " 08/01/2009 - "Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer." 06/01/2009 - "Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension." 08/01/2009 - "The abundant presence of angiotensin-converting enzyme 2 (ACE2) in the lungs and its impressive effect in the prevention of acute lung injury led us to test the hypothesis that pulmonary overexpression of this enzyme could produce beneficial outcomes against pulmonary hypertension. "
2.	Hypertension (High Blood Pressure) 12/01/2015 - "Some studies have evaluated the associations between the angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and essential hypertension (EH) risk. " 12/01/2006 - "Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese." 07/01/2004 - "Recent intriguing findings from genetic linkage, knockout, and physiologic studies in mice and rats led us to conduct the first investigation of the novel angiotensin-converting enzyme 2 gene (ACE2) in human hypertension (HT). " 12/01/2015 - "The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients." 07/15/2014 - "It has been reported that tonically active glutamatergic input to the RVLM is increased in hypertensive rats, whereas angiotensin-converting enzyme 2 (ACE2) in the brain has been suggested to be beneficial to hypertension. "
3.	Fibrosis (Cirrhosis) 04/01/2009 - "Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2." 10/15/2010 - "The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension." 03/01/2011 - "Our previous studies have indicated that chronic treatment with 1-[(2-dimethylamino) ethylamino]-4-(hydroxymethyl)-7-[(4-methylphenyl) sulfonyl oxy]-9H-xanthene-9-one (XNT), an angiotensin-converting enzyme 2 (ACE2) activator, reverses hypertension-induced cardiac and renal fibrosis in spontaneously hypertensive rats (SHRs). " 12/01/2015 - "We aimed to evaluate the hepatic immunoreactivity of angiotensin-converting enzyme 2 (ACE2) in non-alcoholic steatohepatitis (NASH) patients, elucidate its association with the clinicopathological characteristics and also determine its role in fibrosis progression. " 05/01/2012 - "Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy."
4.	Cardiovascular Diseases (Cardiovascular Disease) 06/01/2013 - "Thus, this study indicated that angiotensin-converting enzyme 2 activation promotes beneficial effects on the endothelial function and it is a potential target for treating cardiovascular disease." 06/01/2015 - "Angiotensin-converting enzyme 2 (ACE2) is a new member of the renin-angiotensin system (RAS) and it has been proposed that ACE2 is a potential therapeutic target for the control of cardiovascular disease. " 07/01/2014 - "Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases." 08/01/2013 - "Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in?" 01/01/2013 - "Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases."
5.	Uveitis 06/01/2014 - "Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice." 01/01/2015 - "Our previous study demonstrated that an intraperitoneal injection of Diminazene Aceturate (DIZE) attenuated uveitis by activating ocular angiotensin-converting enzyme 2 (ACE2). "

Related Drugs and Biologics

1.	angiotensin I (1-7)
2.	Angiotensin II
3.	diminazene aceturate
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
5.	Angiotensins
6.	Type 1 Angiotensin Receptor
7.	Peptides
8.	telmisartan (Micardis)
9.	Antigens
10.	Serine Proteases (Serine Protease)

Related Therapies and Procedures

1.	Intensive Care (Surgical Intensive Care)
2.	Therapeutics
3.	Surgical Instruments (Clip)
4.	Intraperitoneal Injections
5.	Ketogenic Diet