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2'- deoxy- 5- fluorouridylyl- (5'- 5')- N(4)- octadecyl- 1- arabinofuranosylcytosine

structure in first source

Also Known As:

5-FdU-NOAC

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Cytarabine: 6662
        2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1
    - Pyrimidine Nucleotides: 48
      - Uracil Nucleotides: 40
        Deoxyuracil Nucleotides: 1
        Fluorodeoxyuridylate: 99
        2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Deoxyribonucleotides: 132
    - Deoxyuracil Nucleotides: 1
      - Fluorodeoxyuridylate: 99
        2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1
  - Pyrimidine Nucleotides: 48
    - Uracil Nucleotides: 40
      - Deoxyuracil Nucleotides: 1
        Fluorodeoxyuridylate: 99
        2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Cytarabine: 6662
        2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1
  - Arabinonucleosides: 1
    - Cytarabine: 6662
      - 2'-deoxy-5-fluorouridylyl-(5'-5')-N(4)-octadecyl-1-arabinofuranosylcytosine: 1

Experts

1.	Cattaneo-Pangrazzi, R M: 1 article (09/2000)
2.	Schott, H: 1 article (09/2000)
3.	Schwendener, R A: 1 article (09/2000)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 09/15/2000 - "5-FdU-NOAC inhibits thymidylate synthase and cell cycle progression causing proliferation arrest and apoptosis in DU-145 and PC-3 cells, suggesting a potential role of 5-FdU-NOAC for the treatment of prostate cancer." 09/15/2000 - "The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145."
2.	Neoplasms (Cancer) 09/15/2000 - "We analyzed the cytotoxic properties of the new heterodinucleoside phosphate dimer 5-FdU-NOAC, which is composed of the cytotoxic drugs 5-FdU and N(4)-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) against human prostate tumor cells. "
3.	Carcinoma (Carcinomatosis) 09/15/2000 - "5-FdU-NOAC effects on cell proliferation, cell cycle distribution, thymidylate synthase activity, and apoptosis were investigated in vitro in the two human prostate carcinoma cell lines DU-145 and PC-3 and compared to cells treated with the corresponding single drugs 5-FdU and NOAC. "

Related Drugs and Biologics

1.	Thymidylate Synthase
2.	Phosphates (Orthophosphate)
3.	Androgens
4.	N(4)- octadecyl- 1- arabinofuranosylcytosine
5.	N(4)-oleylcytosine arabinoside
6.	5-formyl-2'-deoxyuridine