TARP

TARP - TCRgamma alternate reading frame protein; expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain; amino acid sequence in first source

Networked: 91 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Essand, Magnus: 7 articles (01/2020 - 08/2003)
2.	Pastan, Ira: 6 articles (12/2018 - 08/2003)
3.	Kato, Akihiko S: 5 articles (01/2019 - 05/2010)
4.	Xia, Hong: 4 articles (10/2022 - 07/2005)
5.	Witkin, Jeffrey M: 4 articles (01/2019 - 01/2017)
6.	Berzofsky, Jay A: 4 articles (12/2018 - 04/2004)
7.	Terabe, Masaki: 4 articles (12/2018 - 04/2004)
8.	Zhang, Kai: 3 articles (10/2022 - 07/2005)
9.	Jewett, Travis J: 3 articles (12/2021 - 09/2010)
10.	De Moerloose, Barbara: 3 articles (11/2021 - 01/2020)

Related Diseases

1.	Infections 10/01/2022 - "Among the remaining 12 patients with DI and O/SI, 11 underwent reoperation for TARP system removal and subsequently one-stage posterior occipitocervical fixation, and one patient experienced infection two months post-operatively and died without receiving treatment. " 01/01/2022 - "However, tarM does not interfere with infection by tarP phages. " 12/01/2021 - "Tarp-dependent disruption of the Hippo pathway was confirmed in a C. trachomatis tissue culture infection model. " 12/01/2021 - "A comprehensive understanding of the host pathways that are controlled by Tarp to aid in the establishment of a successful infection remains incomplete. " 07/12/2010 - "trachomatis-induced cell survival and suggest that Tarp functions as a multivalent phosphorylation-dependent signaling hub that is important during the early phase of chlamydial infection."
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2017 - ": DC factors essential for the activation of immune responses associated with TARP vaccination in prostate cancer patients were identified. " 09/01/2005 - "Among these were several known prostate cancer relevant genes, such as AMACR, TARP, LIM, GPR160 (all up-regulated), CAV1, NTN1, MT1X; CLU, TRIM29, SPARCL1 and HSPB8 (all down-regulated)." 06/04/2004 - "Immunohistochemistry using a human prostate cancer sample showed that TP1 reacted in a dot-like cytoplasmic pattern consistent with the presence of TARP in mitochondria. " 08/01/2003 - "We further demonstrate that the promoter specifically initiates reporter gene expression in TARP-positive prostate cancer cell lines. " 11/15/2001 - "These results suggest that TARP has a role in regulating growth and gene expression in prostate cancer cells."
3.	Neoplasms (Cancer) 05/01/2005 - "The aim of the present study was to use immunohistochemistry and semi-quantitative histomorphometric analysis to compare the distribution and relative abundance of AQP1 on NCI TARP human multiple tumor tissue microarrays (TMAs) with normal tissues represented on the CHTN TMAs. " 10/01/2023 - "Tumor chromosome 3 status and the immunoprofile of the TARP also were collated. " 11/01/2021 - "In this review, we provide an overview of TARP expression, its role in different cancer types, and currently investigated TARP-directed immunotherapeutic options." 11/01/2021 - "Interestingly, TARP promotes tumor cell proliferation and migration, which is reflected in an association with worse survival. " 12/01/2012 - "Our findings demonstrated that the feline TARP ortholog is transcribed in the prostate gland and mammary tumors but not normal mammary tissues as is the case with human TARP."
4.	Disease Progression 05/01/2009 - "Ongoing trials that will further clarify the role of 5-ARIs in preventing and treating PCa include the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) with dutasteride in PCa risk reduction; the Reduction by Dutasteride of Clinical Progression Events in Expectant Management (REDEEM) trial on the effect of dutasteride on disease progression in low-grade localized PCa; and the Therapeutic Assessment of Rising PSAs [prostate-specific antigens] (TARP) trial on dutasteride in asymptomatic recurrent cancer. " 10/01/2009 - "The Therapy Assessed by Rising PSA (TARP) study investigates dutasteride in combination with bicalutamide to prevent or delay disease progression in patients with castrate-refractory prostate cancer (CRPC) after initial androgen deprivation therapy. "
5.	Epilepsy (Aura) 12/06/2017 - "Recent studies show that targeting a TARP auxiliary subunit of AMPA receptors selectively modulates neuronal excitability in specific forebrain pathways relevant to epilepsy. " 05/01/2010 - "Whole-genome analyses also link multiple TARP loci to childhood epilepsy, schizophrenia and bipolar disorder. " 01/01/2018 - "Utilizing these auxiliary proteins in compound screening led to the discovery of the TARP-dependent-AMPA forebrain selective receptor antagonist (TDAA), LY3130481/CERC-611 that is currently in clinical development for epilepsy." 01/01/2017 - "6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]- 3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8 that is under development for epilepsy. " 11/01/2017 - "6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array of acute and chronic epilepsy models in rodents. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	T-Cell Antigen Receptors (T-Cell Receptor)
3.	Antigens
4.	Epitopes
5.	Dutasteride (Avodart)
6.	AMPA Receptors (AMPA Receptor)
7.	Peptides (Polypeptides)
8.	Androgens
9.	Vaccines
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Pedicle Screws
4.	Radiotherapy
5.	Prostatectomy (Retropubic Prostatectomy)