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7-hydroxytheonellasterol

a cytotoxic 4-methylene sterol from the Philippines sponge Theonella swinhoei; structure in first source

Also Known As:

7alpha-hydroxytheonellasterol; theonellasterol

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        7-hydroxytheonellasterol: 2
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - 7-hydroxytheonellasterol: 2

Experts

1.	Bifulco, Giuseppe: 2 articles (11/2012 - 01/2012)
2.	D'Auria, Maria Valeria: 2 articles (11/2012 - 01/2012)
3.	Fiorucci, Stefano: 2 articles (11/2012 - 01/2012)
4.	Zampella, Angela: 2 articles (11/2012 - 01/2012)
5.	Distrutti, Eleonora: 1 article (11/2012)
6.	Chini, Maria Giovanna: 1 article (01/2012)
7.	Cipriani, Sabrina: 1 article (01/2012)
8.	D'Amore, Claudio: 1 article (01/2012)
9.	Mencarelli, Andrea: 1 article (01/2012)
10.	Monti, Maria Chiara: 1 article (01/2012)

Related Diseases

1.	Cholestasis 11/01/2012 - "Selective FXR antagonists (theonellasterol) have proven effective in protecting against liver injury in models of cholestasis. " 01/01/2012 - "Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis." 01/01/2012 - "A proof-of-concept study carried out to investigate whether FXR antagonism rescues mice from liver injury caused by the ligation of the common bile duct, a model of obstructive cholestasis, demonstrated that theonellasterol attenuates injury caused by bile duct ligation as measured by assessing serum alanine aminostrasferase levels and extent of liver necrosis at histopathology. "
2.	Necrosis 01/01/2012 - "A proof-of-concept study carried out to investigate whether FXR antagonism rescues mice from liver injury caused by the ligation of the common bile duct, a model of obstructive cholestasis, demonstrated that theonellasterol attenuates injury caused by bile duct ligation as measured by assessing serum alanine aminostrasferase levels and extent of liver necrosis at histopathology. "

Related Drugs and Biologics

1.	Sterols
2.	Alanine (L-Alanine)

Related Therapies and Procedures

1.	Ligation