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LY 426965

a 5-HT(1A) antagonist; structure in first source

Also Known As:

1-cyclohexyl-4-(4-(2-methoxyphenyl)-1-piperazinyl)-2-methyl-2-phenyl-1-butanone; LY-426965; LY426965

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - LY 426965: 2

Experts

1.	Gray, K: 1 article (06/2003)
2.	Newson, M: 1 article (06/2003)
3.	Pei, Q: 1 article (06/2003)
4.	Sharp, T: 1 article (06/2003)
5.	Sprakes, M: 1 article (06/2003)
6.	Tordera, R: 1 article (06/2003)
7.	Branchek, T A: 1 article (08/2000)
8.	Calligaro, D O: 1 article (08/2000)
9.	Czachura, J F: 1 article (08/2000)
10.	Dreshfield-Ahmad, L J: 1 article (08/2000)

Related Diseases

1.	AIDS-Related Complex (ARC) 06/01/2003 - "Whilst LY 426965 (3 or 10 mg/kg s.c.) had no effect alone, when combined with paroxetine (5 mg/kg s.c.), the drug increased Arc mRNA in caudate putamen but not cortical regions.In" 06/01/2003 - "The present study tested the effect of different selective 5-HT(1A) receptor antagonists (WAY 100635, NAD-299, p-MPPI and LY 426965) in combination with a SSRI (paroxetine), on postsynaptic 5-HT function measured by increased expression of the immediate early gene, Arc. "
2.	Hypothermia 08/01/2000 - "administration, LY426965 blocked the lower lip retraction, flat body posture, hypothermia, and increase in rat serum corticosterone induced by the 5-HT(1A) agonist 8-OH-DPAT (8-hydroxy-2-dipropylaminotetralin). "

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Paroxetine (Paxil)
3.	Serotonin (5 Hydroxytryptamine)
4.	robalzotan
5.	N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamide
6.	4- (2'- methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- iodobenzamido)ethyl)piperazine
7.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
8.	Messenger RNA (mRNA)
9.	Corticosterone