HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

NC 2100

aperoxisome proliferator-activated receptor-gamma (PPARgamma) activator; structure in first source

Also Known As:

NC-2100

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - NC 2100: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - NC 2100: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - NC 2100: 1

Experts

1.	Fukui, Y: 1 article (05/2000)
2.	Masui, S: 1 article (05/2000)
3.	Motojima, K: 1 article (05/2000)
4.	Osada, S: 1 article (05/2000)
5.	Umesono, K: 1 article (05/2000)

Related Diseases

1.

Body Weight (Weight, Body)

05/01/2000 - "Furthermore, NC-2100 caused the smallest body weight increase of the 4 TZDs, which may be partly explained by the finding that NC-2100 efficiently induces uncoupling protein (UCP)-2 mRNA and significantly induces UCP1 mRNA in white adipose tissue (WAT). "
05/01/2000 - "To examine whether activation of PPAR-gamma directly correlates with antidiabetic activities, we compared the effects of 4 TZDs (troglitazone, pioglitazone, BRL-49653, and a new derivative, NC-2100) on the activation of PPAR-gamma in a reporter assay, transcription of the target genes, adipogenesis, plasma glucose and triglyceride levels, and body weight using obese KKAy mice. "

Related Drugs and Biologics

1.	PPAR gamma
2.	Triglycerides (Triacylglycerol)
3.	Messenger RNA (mRNA)
4.	Hypoglycemic Agents (Hypoglycemics)
5.	Glucose (Dextrose)
6.	Troglitazone (Rezulin)
7.	Pioglitazone (Actos)
8.	Rosiglitazone (Avandia)
9.	Mitochondrial Uncoupling Proteins