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pretomanid

nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source
Also Known As:
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine; PA 824; PA-824; PA824 cpd
Networked: 152 relevant articles (16 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nuermberger, Eric L: 11 articles (11/2021 - 01/2011)
2. Dawson, Rodney: 8 articles (02/2021 - 08/2010)
3. Tyagi, Sandeep: 8 articles (01/2021 - 06/2005)
4. Tasneen, Rokeya: 8 articles (01/2020 - 04/2008)
5. Everitt, Daniel: 7 articles (12/2021 - 04/2015)
6. Li, Si-Yang: 7 articles (11/2021 - 12/2011)
7. Barry, Clifton E: 7 articles (01/2014 - 01/2006)
8. Denny, William A: 6 articles (12/2020 - 01/2010)
9. Thompson, Andrew M: 6 articles (12/2020 - 01/2010)
10. Diacon, Andreas H: 6 articles (01/2020 - 08/2010)

Related Diseases

1. Tuberculosis (Tuberculoses)
2. Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
3. Extensively Drug-Resistant Tuberculosis
4. Pulmonary Tuberculosis
5. Infections

Related Drugs and Biologics

1. bedaquiline (R207910)
2. Linezolid (Zyvox)
3. Pyrazinamide
4. Moxifloxacin (Avelox)
5. Rifampin (Rifampicin)
6. Isoniazid (Ftivazide)
7. Aerosols
8. Rifamycins
9. diphenyl (biphenyl)
10. Oxazolidinones (2 Oxazolidone)

Related Therapies and Procedures

1. Duration of Therapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Nebulizers and Vaporizers (Inhaler)
5. Intraperitoneal Injections