activity-dependent neurotrophic factor

Activity-Dependent Neurotrophic Factor Peptide-9 (ADNF9) with full neurotrophic activity

Also Known As:

ADNF peptide; ADNF peptide, human; ADNF peptide, mouse; ADNF peptide, rat; ADNF-14 peptide; ADNF-9 peptide; ADNF9; ADNF9 peptide; activity-dependent neurotrophic factor, human; activity-dependent neurotrophic factor, mouse; activity-dependent neurotrophic factor, rat

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - activity-dependent neurotrophic factor: 14

Experts

1.	Kita, Yoshiko: 4 articles (05/2008 - 11/2004)
2.	Niikura, Takako: 3 articles (05/2008 - 11/2004)
3.	Matsuoka, Masaaki: 3 articles (11/2005 - 11/2004)
4.	Nishimoto, Ikuo: 3 articles (11/2005 - 11/2004)
5.	Zhou, Feng C: 2 articles (08/2008 - 01/2004)
6.	Arakawa, Tsutomu: 2 articles (05/2008 - 01/2007)
7.	Arisaka, Fumio: 2 articles (05/2008 - 01/2007)
8.	Tajima, Hirohisa: 2 articles (01/2007 - 11/2004)
9.	Aiso, Sadakazu: 2 articles (11/2005 - 11/2004)
10.	Chiba, Tomohiro: 2 articles (11/2005 - 11/2004)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 11/15/2004 - "Here we found that activity-dependent neurotrophic factor (ADNF), a neurotrophic factor originally identified to have the anti-Alzheimer's disease (AD) activity, protected against neuronal cell death caused by FALS-linked A4T-, G85R- and G93R-SOD1 in a dose-responsive fashion. " 01/01/2007 - "Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and Alzheimer's disease-related and amyotrophic-lateral-sclerosis-related insults at femto-molar concentrations. " 11/02/2005 - "Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo." 07/01/2012 - "A cholesteryl-functionalized derivative of activity dependent neurotrophic factor-9 peptide (a nine amino acid core peptide of activity-dependent neurotrophic factor, acting against Alzheimer's disease) was synthesized aiming at the improvement of its bioavailability. " 08/10/2005 - "PARP-1 was activated in rat cerebral cortical neurons briefly exposed to NGF-related nerve growth factors and to the neuroprotective peptides NAP (the peptide NAPVSIPQ, derived from the activity-dependent neuroprotective protein ADNP) and ADNF-9 (the peptide SALLRSIPA, derived from the activity-dependent neurotrophic factor ADNF) In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells as well as in the neuroprotective activity of NAP in neurons treated with the Alzheimer's disease neurotoxin beta-amyloid. "
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/01/2008 - "Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and AD-related and amyotrophic lateral sclerosis-related insults at fM concentrations. " 11/15/2004 - "Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo." 01/01/2007 - "Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and Alzheimer's disease-related and amyotrophic-lateral-sclerosis-related insults at femto-molar concentrations. "
3.	Fetal Alcohol Spectrum Disorders 01/01/2004 - "We evaluated a 9-amino-acid peptide, SALLRSIPA (SAL), an agonist of activity-dependent neurotrophic factor (ADNF), for its protective properties against fetal alcohol-related brain growth retardation, using an established liquid diet model of alcohol-related neurodevelopmental disorder (ARND) in C57BL/6 mice. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 07/01/2000 - "Thus, NF-kappaB mediates the neuron survival-promoting effects of ADNF9 in experimental models relevant to developmental neuronal death and neurodegenerative disorders."
5.	Pheochromocytoma 08/10/2005 - "PARP-1 was activated in rat cerebral cortical neurons briefly exposed to NGF-related nerve growth factors and to the neuroprotective peptides NAP (the peptide NAPVSIPQ, derived from the activity-dependent neuroprotective protein ADNP) and ADNF-9 (the peptide SALLRSIPA, derived from the activity-dependent neurotrophic factor ADNF) In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells as well as in the neuroprotective activity of NAP in neurons treated with the Alzheimer's disease neurotoxin beta-amyloid. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Nerve Growth Factors (Neurotrophins)
3.	SALLRSIPA
4.	Nerve Growth Factor (NGF)
5.	Glutamic Acid (Glutamate)
6.	Neuroprotective Agents
7.	NF-kappa B (NF-kB)
8.	Amyloid beta-Peptides
9.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
10.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))