parecoxib

structure in first source

Also Known As:

Dynastat; N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide; N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt; N-(((Me-P)-P)S)P; parecoxib sodium

Networked: 383 relevant articles (77 outcomes, 136 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - parecoxib: 383

Experts

1.	Hubbard, Richard C: 9 articles (10/2004 - 01/2002)
2.	Cheung, Raymond: 7 articles (01/2020 - 03/2007)
3.	Essex, Margaret Noyes: 5 articles (01/2020 - 01/2017)
4.	Li, Chunming: 5 articles (09/2017 - 01/2016)
5.	Joshi, Girish P: 5 articles (01/2009 - 02/2004)
6.	Brown, Mark T: 5 articles (11/2008 - 03/2005)
7.	Verburg, Kenneth M: 5 articles (11/2008 - 03/2005)
8.	Hubbard, R C: 5 articles (11/2004 - 07/2001)
9.	Wang, Wei: 4 articles (01/2021 - 01/2016)
10.	Xie, Li: 4 articles (01/2019 - 01/2016)

Related Diseases

1.	Pain (Aches) 01/01/2022 - "This is the first trial of which the authors are aware, that supports intravenous parecoxib as significantly enhancing patient mobility, in addition to having pain control efficacy, when compared with PCA. " 11/01/2008 - "In the multiday study, patients given parecoxib had significantly improved summed pain intensity through 24 hours and PGESM scores compared with patients receiving placebo. " 11/01/2008 - "In the single-day study, patients receiving parecoxib had significantly improved summed pain intensity difference through 24 hours, time-weighted sum of total pain relief through 24 hours, and Patient's Global Evaluation of Study Medication (PGESM) scores compared with those given placebo. " 08/01/2008 - "Subsequently, 479 randomized patients received double-blind treatment with parecoxib 20 mg bid (n = 159), parecoxib 20 mg qd (n = 159) followed by placebo, or placebo (n = 161) on Day 2. Patients treated with parecoxib 20 mg bid reported significantly lower summed pain intensity over 24 h (SPI-24) scores and improved patients' global evaluation of study medication (PGESM) ratings compared with placebo-treated patients on Days 2 to 5 (P < 0.05). " 01/01/2018 - "Perioperative parecoxib administration was effective in reducing the proportion of patients who required adjuvant pain relief after laparoscopic surgeries without significant adverse events compared with placebo. "
2.	Postoperative Pain 01/01/2018 - "Parecoxib 40 mg significantly improved postoperative pain vs placebo in Korean patients after TKA. " 10/01/2016 - "Our results demonstrate that the perioperative administration of parecoxib significantly improved its effectiveness in the control of postoperative pain after TACE. " 07/01/2003 - "This study suggests that parecoxib, in a dose of 40 mg IM/IV, is an effective and safe option for the management of postoperative pain." 01/01/2017 - "Efficacy of a single 40-mg intravenous dose of parecoxib for postoperative pain control after elective cesarean delivery: A double-blind randomized placebo-controlled trial." 04/15/2009 - "Assess the efficacy of single dose intravenous or intramuscular parecoxib in acute postoperative pain, the requirement for rescue medication, and any associated adverse events. "
3.	Hyperalgesia 12/01/2008 - "In contrast, the central component of hyperalgesia, measured as a reduction in tail flick latency in response to heat, is reduced by parecoxib. " 01/01/2007 - "This hyperalgesia was not attenuated by postoperative injection of parecoxib. " 01/01/2004 - "Similarly, parecoxib reversed the hyperalgesia in the LPS-injected paw but not in the contralateral paw of rats. " 06/01/2021 - "Parecoxib for opioid-induced hyperalgesia." 04/01/2018 - "This hyperalgesia could be partly or totally prevented by the pretreatment of either parecoxib or SC51089. "
4.	Wounds and Injuries (Trauma) 01/01/2005 - "Treatment of skeletal muscle soft-tissue trauma with parecoxib before as well as after injury is highly effective in restoring disturbed microcirculation. " 01/01/2022 - "Parecoxib sodium (Pare) has been shown to exert protective effects against multiple I/R-induced tissue injuries. " 11/01/2021 - "Parecoxib sodium, a selective inhibitor for COX‑2, exerts protective effects, such as reducing I/R‑induced injuries in the heart, kidney and brain. " 10/01/2018 - "Totally, 127 patients who underwent major spine surgery were randomly divided into three groups: pre-group, which received 40 mg parecoxib before skin incision and at 12 and 24 hours after the first dose; post-group, which received the same dose at wound closure and at 12 and 24 hours after the first dose; and control group, which did not receive any parecoxib. " 01/01/2005 - "Seven additional animals received parecoxib two hours after the trauma, and seven animals without trauma served as controls. "
5.	Infarction (Infarctions) 11/01/2007 - "Systolic thickness in the anterior (infarct) wall was also significantly greater in the parecoxib-treated animals (3.2 +/- 0.1 vs. 2.7 +/- 0.1 mm, P = 0.008), while the posterior wall was not significantly affected (P = 0.08). " 12/06/2006 - "We found a significant reduction in infarct volume in parecoxib treated animals one week after tMCAo (p < 0.03). " 02/01/2012 - "Parecoxib significantly diminished infarct volume and attenuated neuron apoptosis in a dose-independent manner, compared with MCAO group alone. " 06/01/2009 - "Parecoxib did not affect infarct size in either group. " 06/01/2007 - "Administration of parecoxib in ischemic CHF provides functional improvement of the peri-infarct myocardium. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Opioid Analgesics (Opioids)
3.	Morphine (MS Contin)
4.	valdecoxib (Bextra)
5.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
6.	Acetaminophen (Paracetamol)
7.	Celecoxib (Celebrex)
8.	Ketorolac
9.	Dipyrone (Metamizole)
10.	lornoxicam

Related Therapies and Procedures

1.	Analgesia
2.	Laparoscopic Cholecystectomy
3.	Gynecologic Surgical Procedures (Gynecologic Surgery)
4.	Injections
5.	Knee Replacement Arthroplasty (Total Knee Replacement)