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trypsin inhibitor MCoTI-II

from seeds of squash, Momordica cochinchinensis; MW 3480.7 Da; amino acid sequence in first sour

Also Known As:

MCoTI-II

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Cyclotides: 54
      - trypsin inhibitor MCoTI-II: 6

Experts

1.	Craik, David J: 4 articles (10/2016 - 01/2007)
2.	Chan, Lai Yue: 2 articles (10/2016 - 01/2016)
3.	Daly, Norelle L: 2 articles (10/2016 - 01/2007)
4.	Wang, Conan K: 2 articles (05/2016 - 01/2016)
5.	De Spiegeleer, Bart: 1 article (05/2016)
6.	Stalmans, Sofie: 1 article (05/2016)
7.	Bokil, Nilesh J: 1 article (01/2016)
8.	Cheneval, Olivier: 1 article (01/2016)
9.	D'Souza, Charlotte: 1 article (01/2016)
10.	Henriques, Sónia Troeira: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/19/2016 - "The grafted MCoTI-II peptides were cytotoxic to a cancer cell line and showed high stability in human serum. " 01/19/2016 - "Overall, this study demonstrates the application of the MCoTI-II scaffold for the development of stable peptide drugs for cancer therapy. " 10/13/2016 - "This is the first report to use the MCoTI-II framework to develop a 2-in-1 anti-angiogenic peptide, which has the potential to be used as a form of combination therapy for targeting a wide range of cancers." 01/19/2016 - "Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer."
2.	Melanoma (Melanoma, Malignant) 08/01/2015 - "In this study, we demonstrated that the cystine-knot peptide MCoTI-II, a trypsin inhibitor from Momordica cochinchinensis, can be engineered to bind to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, that has emerged as a target for the treatment of metastatic melanoma. "
3.	Prostatic Neoplasms (Prostate Cancer) 08/01/2014 - "MCoTI-II also selectively inhibited the invasion of matriptase-expressing prostate cancer cells. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2007 - "Cell uptake was examined for representatives of two cyclotide subfamilies; the first was MCoTI-II, a member of the trypsin inhibitor subfamily, which was internalized by a macrophage and breast cancer cell line and the second, the prototypic cyclotide kalata B1 from the Möbius subfamily, which remained extracellular. "
5.	Brain Neoplasms (Brain Tumor) 05/01/2016 - "The distribution of MCoTI-II was compared with that of chlorotoxin, which is a four-disulfide-containing peptide that has been used to develop brain tumor imaging agents; dermorphin, which is a disulfide-less peptide; and bovine serum albumin, a large protein. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Trypsin Inhibitors
3.	CTLA-4 Antigen
4.	Cystine (L-Cystine)
5.	Cyclotides
6.	Proteins (Proteins, Gene)
7.	Angiogenic Proteins
8.	Bovine Serum Albumin
9.	Cyclic Peptides
10.	Disulfides

Related Therapies and Procedures

1.	Therapeutics