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L 838,417

structure in first source

Also Known As:

L-838,417; L-838417; 1,2,4-Triazolo(4,3-b)pyridazine, 3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Fluorobenzenes: 14
        L 838,417: 9
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorobenzenes: 14
        L 838,417: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - L 838,417: 9

Experts

1.	Deng, Jiao: 1 article (09/2021)
2.	Dong, Hailong: 1 article (09/2021)
3.	Fan, Ze: 1 article (09/2021)
4.	Fang, Zongping: 1 article (09/2021)
5.	Guo, Yaru: 1 article (09/2021)
6.	Han, Jing: 1 article (09/2021)
7.	Hou, Wugang: 1 article (09/2021)
8.	Xiong, Lize: 1 article (09/2021)
9.	Xu, Feifei: 1 article (09/2021)
10.	Zhang, Jinming: 1 article (09/2021)

Related Diseases

1.	Memory Disorders (Memory Loss) 09/16/2021 - "More importantly, activation of α5GABAARs by L-838,417 abrogated the protective effects of Tat-CIRP-CMA against anesthesia and surgery-induced spatial reference learning and memory deficits. "
2.	Neuralgia (Stump Neuralgia) 01/01/2011 - "In this study, we have investigated the effects of the medium-efficacy positive allosteric modulator (PAM) L-838,417 and the low-efficacy PAM TPA023 in a number of preclinical inflammatory and neuropathic pain models. " 01/01/2011 - "A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain."
3.	Pain (Aches) 01/17/2008 - "L-838,417 not only diminished the nociceptive input to the brain but also reduced the activity of brain areas related to the associative-emotional components of pain, as shown by functional magnetic resonance imaging in rats. " 05/01/2011 - "[Effect of L-838,417 on pain behavior in a rat model of trigeminal neuralgia]." 12/01/2012 - "Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function."
4.	Hyperalgesia 05/01/2011 - "L-838,417 can effectively improve hyperalgesia in rats with trigeminal neuralgia without causing sedation, motor impairment, or drug tolerance." 01/01/2012 - "Intrathecal and systemic application of L-838,417, a subtype-selective benzodiazepine site agonist (α2, α3, α5), reduced mechanical and heat hyperalgesia after incision, indicating a role of these subunits in mediating incision-induced hyperalgesia. "
5.	Cognitive Dysfunction 01/01/2019 - "Furthermore, the cognitive dysfunctions were normalized by L-838417, an agonist of GABAAα2 receptors enriched in the axonal initial segment. "

Related Drugs and Biologics

1.	7- (1,1- dimethylethyl)- 6- (2- ethyl- 2H- 1,2,4- triazol- 3- ylmethoxy)- 3- (2- fluorophenyl)- 1,2,4- triazolo(4,3- b)pyridazine
2.	Benzodiazepines
3.	GABA-A Receptors (GABA(A) Receptor)
4.	Morphine (MS Contin)
5.	gamma-Aminobutyric Acid (GABA)
6.	Diazepam (Valium)
7.	Saline Solution
8.	3'- (5- (1- hydroxy- 1- methylethyl)benzoimidazol- 1- yl)biphenyl- 2- carbonitrile

Related Therapies and Procedures

1.	Anesthesia