lactate dehydrogenase C4

05/01/1988 - "In this investigation, seminal LDH-X was not detectable in the vasectomized subjects, in patients with azoospermia due to seminiferous tubular damage, nor in patients who showed a marked decrease in sperm concentration (less than 1 X 10(6)/ml). "
08/01/1993 - "Activity of LDH-x exhibited a trend positive to changes in sperm density and became absent in obstructive and vasectomized azoospermia. "
08/01/1993 - "LDH-x in azoospermia: a new diagnostic alternative to vasography and testicular biopsy."
04/01/2002 - "We measured LDH-C4 activity in seminal plasma from infertile men with oligozoospermia or azoospermia using gel electrophoresis. "

09/01/1994 - "Systemic immunization with LDH-C4 did not reduce the overall pregnancy rate but reduced the frequency of embryo resorption and increased litter size significantly. "

04/01/2016 - "Expression of lactate dehydrogenase C in MDA‑MB‑231 cells and its role in tumor invasion and migration."
11/15/2002 - "Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer."
04/01/1985 - "Mouse LDH-C4 was coupled to EL-4 tumor cells. "
08/01/2011 - "We performed kinetic studies to determine whether oxamate analogues are selective inhibitors of LDH-C4, owing to their potential usefulness in fertility control and treatment of some cancers. "
01/01/2022 - "This review highlights the recent findings on LDH-C4 with particular emphasis on its role in male infertility and tumors."

02/01/1997 - "In contrast, study provides evidence that chemically modified LDH-C4 induces high infertility, since 85-100% of mice failed to conceive in two independent sets of experiments. "
02/01/1997 - "The present study examines the application of homologous LDH-C4 after chemical modifications in the immunological infertility of female mice. "
01/01/2022 - "Defects in the catalytic activity of LDH-C4 are key to pathophysiological abnormalities underlying infertility. "
04/01/2013 - "In addition, lactate dehydrogenase C4 (LDH-C4) gene disorders has been shown to cause impaired sperm motility, leading to infertility in male mice. "
11/01/2003 - "Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. "

01/01/1982 - "Absence of sperm-specific lactate dehydrogenase-x in patients with testis cancer."
01/01/2022 - "LDH-C4 was originally thought to be present only in mature testis and spermatozoa; however, recent studies have implicated LDH-C4 as a cancer-testis antigen (CTA), owing to its aberrant transcription in a broad spectrum of human neoplasms. "
01/01/2022 - "The cancer testis antigen (CTA) lactate dehydrogenase C (LDHC) is a promising anticancer target with tumor-specific expression and immunogenicity. "
04/01/2020 - "Lactate dehydrogenase C4 (LDH-C4) as a cancer/testis antigen (CTA) is abnormally expressed in some malignant tumors. "
04/01/2020 - "Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer."