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tamandarin A

Also Known As:

2-Hiv-didemnin B; didemnin B, Hiv(2)-; didemnin B, alpha-hydroxyisovaleryl(2)-; tamandarin-A

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - tamandarin A: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - tamandarin A: 2

Experts

1.	Epifanio, R A: 1 article (02/2000)
2.	Fenical, W: 1 article (02/2000)
3.	Vervoort, H: 1 article (02/2000)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 10/21/1999 - "[formula: see text] Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1)."
2.	Neoplasms (Cancer) 02/11/2000 - "The cytotoxicity of tamandarin A (1) was evaluated against various human cancer cell lines and shown to be slightly more potent than didemnin B. "

Related Drugs and Biologics

1.	didemnins