2- (4- nitrophenyl)- 4- (4- fluorophenyl)- 5- (4- pyridinyl)- 1H- imidazole

p38 MAP kinase inhibitor

Also Known As:

4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole; PD 169316; PD-169316; PD168316; PD169316; Pyridine, 4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl)-

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole: 10

Experts

1.	Cambier, Ludivine: 1 article (10/2019)
2.	De Vuyst, Evelyne: 1 article (10/2019)
3.	Evrard, Céline: 1 article (10/2019)
4.	Faway, Emilie: 1 article (10/2019)
5.	Lambert de Rouvroit, Catherine: 1 article (10/2019)
6.	Mignon, Bernard: 1 article (10/2019)
7.	Poumay, Yves: 1 article (10/2019)
8.	Thiry, Marc: 1 article (10/2019)
9.	Jeong, Hoiseon: 1 article (08/2013)
10.	Kim, Aeree: 1 article (08/2013)

Related Diseases

1.	Chondrosarcoma 04/29/2004 - "Here, we demonstrate a significant reduction in rat chondrosarcoma cell proliferation following treatment with pharmacological inhibitors (SB202190 and PD169316) of p38 mitogen-activated protein (MAP) kinases. "
2.	Prostatic Neoplasms (Prostate Cancer) 08/01/2003 - "In the current study, we have examined the expression and activation of mitochondrial calpain in Jurkat T leukemia cells, MCF-7 breast carcinoma and LNCaP prostate cancer cells during apoptosis induced by an anticancer drug (VP-16, tamoxifen) or the specific p38 kinase inhibitor PD-169316. "
3.	Memory Disorders (Memory Loss) 06/15/2012 - "In this study, we investigated the effect of intracerebroventricular administration of ERK and p38 specific inhibitors, U0126 and PD169316, respectively, on learning and memory deficits induced by amyloid beta (Aβ) in rats. "
4.	Leukemia 08/01/2003 - "In the current study, we have examined the expression and activation of mitochondrial calpain in Jurkat T leukemia cells, MCF-7 breast carcinoma and LNCaP prostate cancer cells during apoptosis induced by an anticancer drug (VP-16, tamoxifen) or the specific p38 kinase inhibitor PD-169316. "
5.	Breast Neoplasms (Breast Cancer) 08/01/2003 - "In the current study, we have examined the expression and activation of mitochondrial calpain in Jurkat T leukemia cells, MCF-7 breast carcinoma and LNCaP prostate cancer cells during apoptosis induced by an anticancer drug (VP-16, tamoxifen) or the specific p38 kinase inhibitor PD-169316. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Proteins (Proteins, Gene)
3.	Mitogens
4.	4- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazole
5.	U 0126 (UO 126)
6.	Amyloid beta-Peptides
7.	Calpain
8.	p38 Mitogen-Activated Protein Kinases
9.	SB 203580
10.	Mitogen-Activated Protein Kinase Kinases (MEKs)