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tris(8-quinolinolato)gallium (III)

has antineoplastic activity

Also Known As:

GaQ3; KP46 compound; tris(8-quinolinolato)gallium(III); tris-(8-quinolinolato)Ga III

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - tris(8-quinolinolato)gallium (III): 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Hydroxyquinolines: 9
        Oxyquinoline: 287
        tris(8-quinolinolato)gallium (III): 5

Experts

1.	Jakupec, Michael A: 2 articles (11/2006 - 01/2004)
2.	Keppler, Bernhard K: 2 articles (11/2006 - 01/2004)
3.	Gogna, Rajan: 1 article (01/2013)
4.	Keppler, Bernhard: 1 article (01/2013)
5.	Madan, Esha: 1 article (01/2013)
6.	Pati, Uttam: 1 article (01/2013)
7.	Arion, Vladimir B: 1 article (11/2006)
8.	Berger, Roland: 1 article (11/2006)
9.	Foteeva, Lidia S: 1 article (11/2006)
10.	Kowol, Christian: 1 article (11/2006)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2005 - "Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV)." 09/26/2023 - "As shown by IncuCyte Zoom imaging proliferation assays, invasive triple-negative human breast MDA-MB-231 cancer cells treated with sub-toxic doses (5.0-20 μM, 72 h) of [GaQ3 ] (Q=8-hydroxyquinolinato) caused profound morphological changes and inhibition of cell migration, which were likely due to terminal cell differentiation or similar phenotypical change. " 01/01/2013 - "Here we have shown that in cancer cells treated with anti-neoplastic drug GaQ3, p53, there is an increase in intracellular calcium levels by transcriptional regulation of a novel calcium channel gene TRPC6. " 01/01/2004 - "The limitations experienced with gallium nitrate and gallium chloride, which call for a prolonged exposure to low steady-state gallium levels in blood in order to adequately exploit the affinity of gallium to tumor tissues and to avoid severe toxic effects, may be overcome by oral gallium complexes such as tris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III) (gallium maltolate) or tris(8-quinolinolato)gallium(III) (KP46), which are currently being evaluated in clinical trials and show promise to initiate a revival of gallium in the clinical setting. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 11/01/2006 - "A range of novel gallium coordination compounds with established cytotoxic efficacy have been characterized in terms of desirable chemical and biochemical properties and compared with tris(8-quinolinolato)gallium(III) (KP46), a lead anticancer gallium-based candidate that successfully finished phase I clinical trials (under the name FFC11), showing activity against renal cell cancer. "

Related Drugs and Biologics

1.	Gallium
2.	gallium maltolate
3.	gallium chloride
4.	gallium nitrate
5.	Calcium Channels (Calcium Channel)
6.	Calcium
7.	TRPC6 Cation Channel