macrophomate synthase

catalyzes the multistep conversion of 2-pyrones to benzoates

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Dehydration (Water Stress) 12/08/2000 - "Macrophomate synthase from the fungus Macrophoma commelinae IFO 9570 is a Mg(II)-dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical transformation from 2-pyrone and oxalacetate to benzoate involving decarboxylation, C-C bond formation, and dehydration. " 12/08/2000 - "Incubation of the stereospecifically deuterium-labeled malate with 2-pyrones in the presence of malate dehydrogenase provided information for the stereochemical course of the reaction catalyzed by macrophomate synthase, indicating that the first decarboxylation provides pyruvate (Z)-[3-(2)H]enolate and that dehydration at the final step occurs with anti-elimination accompanied by concomitant decarboxylation. " 07/01/2004 - "Macrophomate synthase (MPS) is an enzyme that catalyzes an extraordinarily complex conversion reaction, including two decarboxylations, two carbon-carbon bond formations and a dehydration, to form the benzoate analogue macrophomate from a 2-pyrone derivative and oxalacetate. "
2.	Conversion Disorder (Astasia Abasia) 07/01/2004 - "Macrophomate synthase (MPS) is an enzyme that catalyzes an extraordinarily complex conversion reaction, including two decarboxylations, two carbon-carbon bond formations and a dehydration, to form the benzoate analogue macrophomate from a 2-pyrone derivative and oxalacetate. "

1.	Enzymes
2.	Benzoates (Benzoate)
3.	2-pyrone
4.	Pyruvic Acid (Pyruvate)
5.	Malate Dehydrogenase (Dehydrogenase, Malate)
6.	Deuterium
7.	Carbon
8.	malic acid (malate)