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Leu-M1 antigen
an antigen in malignant mesothelioma
Also Known As:
LeuM1 antigen
Networked:
12
relevant articles (
0
outcomes,
3
trials/studies)
Bio-Agent Context: Research Results
Biological Factors: 2472
Biomarkers: 240291
Tumor Biomarkers: 15272
Carbohydrate Tumor-Associated Antigens: 355
Lewis X Antigen: 164
Leu-M1 antigen: 12
Differentiation Antigens: 2082
Myelomonocytic Differentiation Antigens: 1
Lewis X Antigen: 164
Leu-M1 antigen: 12
Antigens: 143924
Epitopes: 19548
Carbohydrate Tumor-Associated Antigens: 355
Lewis X Antigen: 164
Leu-M1 antigen: 12
Neoplasm Antigens: 6217
Carbohydrate Tumor-Associated Antigens: 355
Lewis X Antigen: 164
Leu-M1 antigen: 12
Surface Antigens: 5813
Blood Group Antigens: 5213
Lewis Blood Group Antigens: 208
Lewis X Antigen: 164
Leu-M1 antigen: 12
Differentiation Antigens: 2082
Stage-Specific Embryonic Antigens: 51
Lewis X Antigen: 164
Leu-M1 antigen: 12
Myelomonocytic Differentiation Antigens: 1
Lewis X Antigen: 164
Leu-M1 antigen: 12
Isoantigens: 1221
Blood Group Antigens: 5213
Lewis Blood Group Antigens: 208
Lewis X Antigen: 164
Leu-M1 antigen: 12
Related Diseases
1.
Hodgkin Disease (Hodgkin's Disease)
04/01/1986 - "
Several studies have shown that the Leu-M1 antigen, a monocyte/granulocyte-related marker, is consistently expressed by the neoplastic cells of patients with Hodgkin's disease (HD).
"
01/01/1987 - "
Leu-M1 antigen is a monocyte/granulocyte-related marker known to be consistently expressed in the Reed-Sternberg cells of patients with Hodgkin's disease.
"
07/01/1986 - "
The pattern of Leu-M1 antigen expression was identical to that previously reported in the Reed-Sternberg cells of Hodgkin's disease.
"
03/01/1995 - "
Comparison of the pattern of expression of Leu-M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy.
"
01/01/1988 - "
Leu-M1 antigen is a monocyte/granulocyte-related marker known to be consistently expressed in the Reed-Sternberg cells of patients with Hodgkin's disease and to be present in tumour cells of a variety of non-haematopoietic neoplasms, most of them adenocarcinomas.
"
2.
Neoplasms (Cancer)
11/01/1986 - "
Unexpectedly, a dermatopathic lymph node from the same patient showed the presence of the Leu-M1 antigen on the majority of normal-appearing interdigitating reticulum cells; this was not the case with control dermatopathic lymph nodes from patients without a malignancy.
"
04/01/1986 - "
Leu-M1 antigen in human neoplasms.
"
12/01/1985 - "
Leu-M1 antigen expression in T-cell neoplasia.
"
07/01/1986 - "
Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides.
"
04/01/1986 - "
To evaluate the significance of the Leu-M1 positivity of Reed-Sternberg cells in the diagnosis of HD, we investigated the distribution of Leu-M1 antigen in a series of patients with HD, non-Hodgkin's lymphomas, and nonhematopoietic neoplasms.
"
3.
Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)
02/01/1988 - "
The significance of sialylation of Leu-M1 antigen in histiocytosis X cells has yet to be determined in order to correlate the prognosis of the disease.
"
02/01/1988 - "
Expression of sialylated Leu-M1 antigen in histiocytosis X.
"
02/01/1988 - "
In this study, the authors tested the usefulness of anti-Leu-M1 in staining formalin-fixed and paraffin-embedded tissue sections from eight patients with histiocytosis X. For staining of histiocytosis X cells, unlike Reed-Sternberg cells in Hodgkin's disease, neuraminidase treatment was required for removal of sialic acid residues from the Leu-M1 antigen.
"
4.
Adenocarcinoma
03/01/1995 - "
Comparison of the pattern of expression of Leu-M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy.
"
01/01/1988 - "
Leu-M1 antigen is a monocyte/granulocyte-related marker known to be consistently expressed in the Reed-Sternberg cells of patients with Hodgkin's disease and to be present in tumour cells of a variety of non-haematopoietic neoplasms, most of them adenocarcinomas.
"
04/01/1986 - "
We were able to demonstrate the presence of Leu-M1 antigen not only in the majority of patients with HD, but also in 12 of 18 (67%) peripheral T-cell lymphomas, as well as in a variety of nonhematopoietic neoplasms, which included 113 of 199 carcinomas, most of them (58%) adenocarcinomas.
"
5.
Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
12/01/1985 - "
The Leu-M1 antigen has been recently proposed as a valuable immunodiagnostic marker of the Reed-Sternberg cells of Hodgkin's disease and to be particularly helpful is distinguishing Hodgkin's disease from other lymphoproliferative disorders such as peripheral T-cell lymphomas.
"
04/01/1986 - "
We were able to demonstrate the presence of Leu-M1 antigen not only in the majority of patients with HD, but also in 12 of 18 (67%) peripheral T-cell lymphomas, as well as in a variety of nonhematopoietic neoplasms, which included 113 of 199 carcinomas, most of them (58%) adenocarcinomas.
"
Related Drugs and Biologics
1.
Paraffin
2.
N-Acetylneuraminic Acid (Sialic Acid)
3.
Neuraminidase (Sialidase)
4.
Formaldehyde (Formol)
5.
Plastics
6.
S100 Proteins (S 100 Protein)
7.
Blood Group Antigens (Blood Groups)