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7- chloro- 3- imino- 5- methyl- 2- azabicyclo(4.1.0)heptane

inhibits inducible NO synthase; ONO-1714 is the HCl salt; structure in first source

Also Known As:

ONO 1714; ONO-1714

Networked: 28 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane: 28
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane: 28

Experts

1.	Kamanaka, Yoshihisa: 5 articles (08/2008 - 12/2003)
2.	Maruyama, Takayuki: 3 articles (08/2008 - 03/2006)
3.	Naka, Masao: 3 articles (08/2008 - 03/2006)
4.	Takahashi, Mami: 3 articles (08/2008 - 03/2006)
5.	Wakabayashi, Keiji: 3 articles (08/2008 - 03/2006)
6.	Naito, Yuji: 3 articles (04/2007 - 05/2004)
7.	Yoshikawa, Toshikazu: 3 articles (04/2007 - 05/2004)
8.	Iwasaki, Yoshinobu: 2 articles (10/2008 - 04/2007)
9.	Marunaka, Yoshinori: 2 articles (10/2008 - 04/2007)
10.	Mutoh, Michihiro: 2 articles (08/2008 - 03/2006)

Related Diseases

1.	Colitis 08/01/2007 - "Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice." 08/01/2007 - "In the current study, we investigated the effect of a selective iNOS inhibitor, ONO-1714 on colitis-related colon carcinogenesis in the Apc(Min/+) mouse treated with DSS. " 01/19/2001 - "The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice."
2.	Stroke (Strokes) 08/01/2012 - "In an experimental permanent stroke model, we report here the contribution of ONO-1714 to brain damage prevention. " 08/01/2012 - "Results of this study provide evidence of a significant reduction of the brain lesion size, suggesting ONO-1714 as a potential neuroprotective agent in stroke patients. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 01/19/2005 - "Male Sprague-Dawley rats were subjected to contusive spinal cord injury and administrated 0.1 mg/kg ONO-1714. " 09/15/2004 - "ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. " 01/19/2005 - "Expression of GDNF in spinal cord injury and its repression by ONO-1714."
4.	Glomerulonephritis 12/01/2002 - "The selective iNOS inhibitor ONO-1714 may be beneficial for the treatment of crescentic glomerulonephritis." 12/01/2002 - "To elucidate the role of iNOS in the pathogenesis of experimental crescentic glomerulonephritis, we examined the effect of ONO-1714 given to rats with nephrotoxic serum (NTS) nephritis. "
5.	Colonic Neoplasms (Colon Cancer) 08/01/2007 - "Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice." 08/01/2007 - "The tumor inhibitory effects by ONO-1714 were assessed at week 5 by counting the incidence and multiplicity of colonic neoplasms. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Nitric Oxide Synthase (NO Synthase)
3.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Heptanes
6.	Endotoxins
7.	Ceruletide
8.	3-nitrotyrosine
9.	Nitrites
10.	Nitrates

Related Therapies and Procedures

1.	Catheters
2.	Warm Ischemia
3.	Punctures
4.	Ligation
5.	Controlled Hypotension