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gymnodimine

a spiro-imine algal toxin; a neurotoxic shellfish poison produced by Karenia selliformis (formerly Gymnodinium selliforme) and related species

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - gymnodimine: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - gymnodimine: 4
- Imines: 310
  - gymnodimine: 4

Experts

1.	Bandarra, Narcisa M: 1 article (04/2022)
2.	Botelho, Maria João: 1 article (04/2022)
3.	Milinovic, Jelena: 1 article (04/2022)
4.	Vale, Carlos: 1 article (04/2022)
5.	Alonso, Eva: 1 article (01/2011)
6.	Botana, Luis M: 1 article (01/2011)
7.	Giménez-Llort, Lydia: 1 article (01/2011)
8.	Laferla, Frank M: 1 article (01/2011)
9.	Vale, Carmen: 1 article (01/2011)
10.	Vieytes, Mercedes R: 1 article (01/2011)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2011 - "Altogether these results indicate that the marine phycotoxin gymnodimine may constitute a valuable tool for the development of drugs to treat neurodegenerative diseases." 04/02/2022 - "This study focused on yessotoxins (YTXs), gymnodimine (GYM), spirolides (SPXs), and gambierol, all toxins that have been shown to reduce β-amyloid plaques and tau hyperphosphorylation, thus preventing the neuronal or synaptic dysfunction that ultimately causes the cell death associated with AD (or other neurodegenerative diseases). "
2.	Amyloid Plaque 04/02/2022 - "This study focused on yessotoxins (YTXs), gymnodimine (GYM), spirolides (SPXs), and gambierol, all toxins that have been shown to reduce β-amyloid plaques and tau hyperphosphorylation, thus preventing the neuronal or synaptic dysfunction that ultimately causes the cell death associated with AD (or other neurodegenerative diseases). "
3.	Neuroblastoma 09/01/2002 - "In contrast to earlier versions of the neuroblastoma assay, gymnodimine was not detected by this modified method." 09/01/2005 - "The effects of the shellfish toxin gymnodimine and its analogues (gymnodimine acetate, gymnodimine methyl carbonate and gymnodamine) on cellular viability were tested using the Neuro2a neuroblastoma cell line. "
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2011 - "In this work, we evaluated the effect of long term exposure of cortical neurons to gymnodimine in the progress of Alzheimer disease (AD) pathology in vitro. " 01/01/2011 - "The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease."

Related Drugs and Biologics

1.	gambierol
2.	Cholinergic Antagonists (Anticholinergics)
3.	Acetates (Acetic Acid Esters)
4.	methyl carbonate (dimethyl carbonate)