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NPHS2 protein

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encodes the glomerular protein podocin

Also Known As:

NPHS2 protein, human; Nphs2 protein, mouse; Nphs2 protein, rat; PDCN protein, human; SRN1 protein, human; nephrosis 2 homolog, podocin (human) protein, mouse; nephrosis 2 protein, rat; nephrosis 2, idiopathic, steroid-resistant (podocin) protein, human; podocin; podocin protein, human; podocin protein, mouse; podocin protein, rat

Networked: 228 relevant articles (8 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - NPHS2 protein: 228
  - Intracellular Signaling Peptides and Proteins: 22
    - NPHS2 protein: 228
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - NPHS2 protein: 228

Experts

1.	Kawachi, Hiroshi: 12 articles (08/2014 - 01/2003)
2.	Ghiggeri, Gian Marco: 12 articles (07/2013 - 07/2002)
3.	Antignac, Corinne: 11 articles (02/2014 - 04/2002)
4.	Caridi, Gianluca: 11 articles (07/2013 - 07/2002)
5.	Hildebrandt, Friedhelm: 7 articles (04/2010 - 03/2004)
6.	Benzing, Thomas: 6 articles (07/2014 - 07/2003)
7.	Saleem, Moin A: 6 articles (02/2014 - 10/2002)
8.	Ding, Jie: 6 articles (05/2006 - 11/2003)
9.	Guan, Na: 6 articles (05/2006 - 11/2003)
10.	Miyauchi, Naoko: 5 articles (08/2014 - 06/2005)

Related Diseases

1.	Proteinuria 01/01/2015 - "In this study, we performed a meta-analysis of the published data to investigate the impact of the oligoallelic AA mutations of the podocin on proteinuria; a total 16 AA mutations were investigated for oligoallelic pathogenicity. " 01/01/2015 - "While many previous studies have reported an association between the single-nucleotide polymorphisms (SNPs) of the podocin and proteinuria occurred, a conclusive relationship has not been defined in every oligoallelic state of amino acid (AA) mutations in podocin. " 11/01/2004 - "In order to study a potential pathomechanism of massive proteinuria in patients with SRN, we have investigated the trafficking and subcellular localization of five common disease-causing missense mutants of human podocin. " 01/01/2015 - "The amino acid mutations of the podocin in proteinuria: a meta-analysis." 12/01/2013 - "Reduction of glomerular podocin expression found in MCD and FSGS is related to the amount of proteinuria. "
2.	Albuminuria 08/01/2014 - "Furthermore, BRD attenuated albuminuria and prevented the loss of glomerular podocin expression in these diabetic animals. " 12/01/2011 - "In this pathological process, glomerular podocin expression became faint, especially at 36 hr post-LPS challenge (i.e., a peak of albuminuria). " 10/01/2009 - "The development of significant albuminuria in this model occurred only after early and focal foot process effacement had progressed to diffuse involvement, with complete absence of podocin immunolabeling at the slit diaphragm. " 11/01/2008 - "The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adults." 02/01/2005 - "However, the first change induced by PA was the change of podocin localization from a linear pattern to a dot-like one prior to the onset of albuminuria."
3.	Nephrotic Syndrome (Syndrome, Nephrotic) 10/01/2011 - "We searched Medline and Pubmed using the combination of keywords "NPHS2", "podocin", "steroid-resistant nephrotic syndrome," and "genetics" to identify studies describing an association between NPHS2 gene and renal disease. " 06/01/2005 - "Recent studies on gene mutations encoding podocin and other components of the slit-diaphragm in patients with native kidney nephrotic syndrome have underscored the heterogenecity of the idiopathic form of FSGS. " 10/01/2015 - "Mutations in podocin (NPHS2) are the most common cause of childhood onset autosomal recessive steroid-resistant nephrotic syndrome (SRNS). " 05/01/2015 - "Novel gene mutations have been uncovered in patients with nephrotic syndrome combined with a better definition of the role of podocin mutations. " 08/06/2014 - "Podocin was identified as a gene product of NPHS2, a gene for a familial steroid-resistant nephrotic syndrome of French. "
4.	Membranous Glomerulonephritis (Membranous Nephropathy) 06/01/2005 - "Nephrin is dissociated from podocin and excreted into urine in the early stages of Heymann nephritis. " 06/01/2005 - "Shifts in nephrin and podocin staining patterns, from linear to granular, were detected in the early stages of passive Heymann nephritis. " 08/01/2009 - "Some recent studies demonstrated that podocin, CD2-associated protein and NEPH1 are also functional molecules in the slit diaphragm, and their expressions are altered in membranous nephropathy and also in focal glomerulosclerosis. " 06/01/2005 - "The reduced expression of nephrin and podocin, along with their dissociation, may contribute to the development of proteinuria in Heymann nephritis." 06/01/2005 - "Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy."
5.	Body Weight (Weight, Body) 01/01/2012 - "In diabetic mice, orally administration of genipin postponed the progression of DN, as demonstrated by ameliorating body weight loss and urine albumin leakage, attenuating glomerular basement membrane thickness, restoring the podocyte expression of podocin and WT1 in diabetic mice. " 06/22/2011 - "In Experiment 3, the medium dosage (75 mg/kg body weight) of GTW improved proteinuria, the partial matrix expansion, and the distribution of nephrin and podocin on day 14, as compared with anti-Thy1.1 GN rats (P<0.05). " 06/22/2011 - "In Experiment 2, the high dosage (100mg/kg body weight) of GTW ameliorated proteinuria, the distribution of nephrin and podocin, mesangial proliferation, and the activated macrophage accumulation, as compared with vehicle group (P<0.05). " 08/01/2011 - "WT+STZ mice showed increased kidney:body weight ratio due to cell hypertrophy, increased albuminuria, decreased kidney nephrin, podocin, and podocyte number and increased transforming growth factor-β and laminin compared with WT mice. " 01/01/2013 - "Body weight and 24 h urinary protein ration (Upro) in all rats were measured at day 0, 3, and 9. All rats were sacrificed at day 11 after the establishment of the model, and their blood and renal tissues were collected to observe such blood biochemical indicators including albumin (Alb), serum creatinine (Scr), blood urea nitrogen (BUN) and glomerular ultrastructure (podocyte foot process form) and expressions of dicer enzyme, nephrin, podocin and synaptopodin in renal tissues. "

Related Drugs and Biologics

1.	nephrin
2.	podocalyxin
3.	Creatinine
4.	Collagen
5.	Fibronectins (Fibronectin)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Sirolimus (Rapamycin)
8.	CB1 Cannabinoid Receptor (CB1 Receptor)
9.	Protein Isoforms (Isoforms)
10.	Integrins

Related Therapies and Procedures

1.	Plasmapheresis
2.	Kidney Transplantation
3.	Homologous Transplantation (Allograft)
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration