O-methyl-serine dodecylamide hydrochloride

01/01/2022 - "We report the first methods to establish patient-derived mSDH tumor models, which can be readily employed for understanding patient-specific tumor biology and treatment strategies. "
01/01/2022 - "Molecular and metabolic characterization of our patient-derived mSDH GIST models revealed that these models recapitulate the transcriptional and metabolic hallmarks of parent tumors and SDH deficiency. "
01/01/2022 - "We describe methods for establishing novel patient-derived SDH-mutant (mSDH) GIST models and interrogated the efficacy of temozolomide on these tumor models in vitro and in clinical trials of patients with mSDH GIST. "

01/01/2019 - "Syphilis PS allowed MSDH to interact with 1592 men who have sex with men over a 30-month period and was effective for identifying people newly infected with early syphilis and HIV. "
01/01/2019 - "The Mississippi State Department of Health (MSDH) integrated partner HIV testing into syphilis partner services (PS) in 2014, but the effectiveness of this as an HIV case finding strategy has not been evaluated. "

03/17/2000 - "At high concentrations, MSDH caused extensive lysosomal rupture and necrosis. "
09/01/2003 - "Furthermore, in mixtures of rat liver lysosomes and mitochondria, selective rupture of lysosomes by MSDH promotes mitochondrial ROS production and cytochrome c release, whereas MSDH has no direct effect on ROS generation by purifed mitochondria. "
03/17/2000 - "When MSDH was applied at low concentrations, resulting in partial lysosomal rupture, activation of pro-caspase-3-like proteases and apoptosis followed after some hours. "
12/01/2006 - "Experimental lysosomal rupture by the lysosomotropic drug O-methyl-l-serine dodecylamide hydrochloride (MSDH) induces apoptosis in GC B-cells, including phosphatidyl serine exposure, mitochondrial inactivation, and DNA fragmentation. "
09/01/2003 - "Indeed, in intact cells (J774 macrophages, HeLa cells and AG1518 fibroblasts) the lysosomotropic detergent O-methyl-serine dodecylamide hydrochloride (MSDH) causes lysosomal rupture, enhanced intracellular ROS production, and apoptosis. "

02/01/2015 - "according to MSDH, most men with AIDS were between 30 and 49 years old (68.1%), mixed race (59.4%), heterosexual (46.4%), single (64.5%), Catholic (68.8%), had a bachelor's degree (39.2%), had no children (61.6%), and had a formal job (71.0%). "
02/01/2015 - "A form based on the MSDH was used to collect sociodemographic data addressing individual, proximal, intermediate determinants and the influence of social networks together with an instrument used to assess the QoL of people with HIV/AIDS. "
02/01/2015 - "to analyze the quality of life (QoL) of men with AIDS from the perspective of the model of social determinants of health (MSDH). "
12/01/1991 - "Vicksburg physicians and MSDH join forces on HIV/AIDS clinic."

10/26/2001 - "On October 25, 2000, the Mississippi State Department of Health (MSDH) notified CDC that, since November 1999, 31 inmates had acquired methicillin-resistant Staphylococcus aureus (MRSA) skin or soft tissue infections at a state prison. "