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Ro 631908

an NMDA receptor NR2B subunit blocker; structure in first source

Also Known As:

Ro 63-1908; Ro-63-1908; Ro-631908

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Ro 631908: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Ro 631908: 3

Experts

1.	Higgins, Guy A: 1 article (01/2018)
2.	MacMillan, Cam: 1 article (01/2018)
3.	Silenieks, Leo B: 1 article (01/2018)
4.	Thevarkunnel, Sandy: 1 article (01/2018)
5.	Zeeb, Fiona D: 1 article (01/2018)
6.	Alanine, A: 1 article (09/2002)
7.	Bourson, A: 1 article (09/2002)
8.	Buttelmann, B: 1 article (09/2002)
9.	Fischer, G: 1 article (09/2002)
10.	Gill, R: 1 article (09/2002)

Related Diseases

1.	Stroke (Strokes) 02/18/2000 - "Ro 63-1908 belongs to a class of neuroprotective N-methyl-D-aspartate (NMDA) receptor blockers which were in development for the treatment of stroke and traumatic brain injury. "
2.	Seizures (Absence Seizure) 09/01/2002 - "Ro 63-1908 was active against sound-induced seizures (ED(50) = 4.5 mg/kg i.p. " 09/01/2002 - "NMDA-induced seizures were also inhibited by Ro 63-1908 with an ED(50) of 2.31 mg/kg i.v. when administered 15 min before testing. "
3.	Ischemia 09/01/2002 - "Ro 63-1908 gave a dose-related neuroprotective effect against cortical damage in a model of permanent focal ischemia. "
4.	Gambling (Pathological Gambling) 01/01/2018 - "Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task."
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 02/18/2000 - "Ro 63-1908 belongs to a class of neuroprotective N-methyl-D-aspartate (NMDA) receptor blockers which were in development for the treatment of stroke and traumatic brain injury. "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Neuroprotective Agents
4.	Dizocilpine Maleate (Dizocilpine)