proto-oncogene proteins pim

01/01/2017 - "The aim of this study was to discover a novel pan-Pim kinases inhibitor with potent anti-proliferative activities against cancer cell lines. "
01/01/2023 - "Inhibition of PIM kinases is a potential novel strategy for overcoming BETi persistence in myeloid neoplasms. "
01/01/2023 - "Introduction: PIM kinases are targets for therapeutic intervention since they are associated with a number of malignancies by boosting cell survival and proliferation. "
01/01/2023 - "Targeting Pim kinases in hematological cancers: molecular and clinical review."
07/22/2022 - "PIM kinases have been identified as potential therapeutic targets in several malignancies. "

07/22/2022 - "Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. "
08/26/2021 - "An assortment of molecules and pathways that are critical to myeloma tumorigenesis has been recognized as the downstream targets of PIM kinases. "
06/15/2019 - "This review comprehensively focuses on pharmacological implications of PIM kinases in oncogenesis, structural insights of PIM inhibitors and their structure-activity relationships (SARs)."
01/01/2018 - "Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. "
11/01/2016 - "Pim kinases primarily deal with three broad categories of functions such as tumorigenesis, protecting cells from apoptotic signals and evading immune attacks. "

07/12/2016 - "In this study, we unravel previously unrecognized interactions and crosstalk between Pim kinases and the Notch signaling pathway, with implications for both breast and prostate cancer. "
11/16/2023 - "Importantly, degradation of PIM kinases was more potent than inhibition of catalytic activity at inducing apoptosis in prostate cancer cell line models. "
01/01/2021 - "Expression and ERG regulation of PIM kinases in prostate cancer."
07/12/2016 - "Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells."
01/01/2015 - "Here we have investigated the ability of Pim kinases to promote metastatic growth of prostate cancer cells in two xenograft models for human prostate cancer. "

08/26/2021 - "PIM Kinases in Multiple Myeloma."
07/17/2015 - "Targeting the Pim kinases in multiple myeloma."
09/24/2020 - "Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. "
01/01/2017 - "Pim kinases have been identified as promising therapeutic targets for hematologic-oncology indications, including multiple myeloma and certain leukemia. "
05/01/2014 - "PIM kinases are upregulated in multiple cancer indications, including lymphoma, leukemia, multiple myeloma, and prostate, gastric, and head and neck cancers. "

01/01/2022 - "PIM kinases were less ubiquitinated in hypoxia than in normoxia, indicating that hypoxia reduced their proteasomal degradation. "
09/01/2018 - "Targeting PIM kinases to oppose hypoxia-mediated therapeutic resistance."
01/01/2016 - "Thus, inhibition of PIM kinases has the potential to oppose hypoxia-mediated therapeutic resistance and induce cell death in the hypoxic tumor microenvironment. "
01/01/2016 - "The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases represent a prosurvival pathway that is upregulated in response to hypoxia, in a HIF-1-independent manner. "
01/01/2016 - "We demonstrate that pharmacologic or genetic inhibition of PIM kinases is significantly more toxic toward cancer cells in hypoxia as compared with normoxia. "