transforming growth factor beta1.2

heterodimer of TGF-beta1 and TGF-beta2; J Biol Chem 1992 Feb 5;267(4):2325-8

Also Known As:

TGF-beta1.2

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Transforming Growth Factor beta: 13953
        transforming growth factor beta1.2: 4
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factor beta: 13953
        transforming growth factor beta1.2: 4
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Transforming Growth Factor beta: 13953
        transforming growth factor beta1.2: 4
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factor beta: 13953
        transforming growth factor beta1.2: 4
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Transforming Growth Factor beta: 13953
      - transforming growth factor beta1.2: 4
  - TGF-beta Superfamily Proteins: 1
    - Transforming Growth Factor beta: 13953
      - transforming growth factor beta1.2: 4

Experts

1.	Bosserhoff, A-K: 1 article (07/2011)
2.	Braig, S: 1 article (07/2011)
3.	Fuchshofer, R: 1 article (07/2011)
4.	Junglas, B: 1 article (07/2011)
5.	Wallner, S: 1 article (07/2011)
6.	Amann, Kerstin: 1 article (05/2009)
7.	Daniel, Christoph: 1 article (05/2009)
8.	Hugo, Christian: 1 article (05/2009)
9.	Stief, Andrea: 1 article (05/2009)
10.	Vogelbacher, Regina: 1 article (05/2009)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 07/12/2011 - "The induction of transforming growth factor beta1, 2 and 3 as well as BMP4 and BMP7 expression in malignant melanoma has been reported before, whereas the expression of an important modulator of these molecules, connective tissue growth factor (CTGF), has not been investigated in melanomas until now. "
2.	Inflammation (Inflammations) 12/01/1997 - "In the above cells, persistent infection induced the de novo synthesis of platelet-derived growth factor A/B and enhanced the release of transforming growth factor beta1/2. These two factors are important mediators of progression from glomerular inflammation to glomerulosclerosis. "
3.	Glioma (Gliomas) 02/01/2002 - "Th2 [interleukin (IL)-6, leukemia inhibitory factor and oncostatin M] and Th3 (transforming growth factor-beta1, 2, 3) cytokine and their receptor transcripts were strongly expressed in almost all glioblastomas and glioma cell lines. "
4.	Glioblastoma (Glioblastoma Multiforme) 02/01/2002 - "Th2 [interleukin (IL)-6, leukemia inhibitory factor and oncostatin M] and Th3 (transforming growth factor-beta1, 2, 3) cytokine and their receptor transcripts were strongly expressed in almost all glioblastomas and glioma cell lines. "
5.	Fibrosis (Cirrhosis) 05/15/2009 - "In contrast, calcineurin phosphatase inhibition through CsA did not ameliorate any of the features of diabetic nephropathy compared with placebo treatment but slightly aggravated glomerular fibrosis without affecting transforming growth factor-beta1/2 or vascular endothelial growth factor. "

Related Drugs and Biologics

1.	Cytokines
2.	Connective Tissue Growth Factor
3.	Oncostatin M
4.	Leukemia Inhibitory Factor
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Interleukins
7.	calcineurin phosphatase
8.	platelet-derived growth factor A