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nitrilotriacetic acid ditetradecylamine

a nitrilotriacetic acid (NTA) chelator lipid used in cancer vaccine development

Also Known As:

NTA-DTDA

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - nitrilotriacetic acid ditetradecylamine: 4
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Nitrilotriacetic Acid: 54
        nitrilotriacetic acid ditetradecylamine: 4

Experts

1.	Altin, Joseph G: 2 articles (10/2005 - 03/2002)
2.	van Broekhoven, Christina L: 2 articles (10/2005 - 03/2002)
3.	Altin, J G: 2 articles (08/2001 - 03/2000)
4.	Easton, C J: 1 article (08/2001)
5.	White, F A: 1 article (08/2001)
6.	Parish, C R: 1 article (03/2000)
7.	Vassiliou, G: 1 article (03/2000)
8.	van Broekhoven, C L: 1 article (03/2000)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2000 - "Initial experiments using murine P815 tumor cells established the optimum conditions for incorporating NTA-DTDA onto the membranes of cells. " 03/01/2000 - "A novel chelator lipid, nitrilotriacetic acid di-tetradecylamine (NTA-DTDA) that, via the NTA group has high affinity for 6His peptide, was used to directly anchor recombinant forms of T cell costimulatory molecules containing a C-terminal 6-His sequence onto tumor cell surfaces. " 10/15/2005 - "Recent studies indicate that the chelator lipid nitrilotriacetic acid ditetradecylamine (NTA-DTDA) can be used to engraft T cell costimulatory molecules onto tumor cell membranes, potentially circumventing the need for genetic manipulation of the cells for development of cell- or membrane-based tumor vaccines. "
2.	Mastocytoma 03/01/2002 - "Our analyses by flow cytometry show that NTA-DTDA can be incorporated into PMV prepared from murine P815 mastocytoma and that the incorporated NTA-DTDA permits anchoring or "engraftment" onto the vesicle surface of hexahistidine-tagged proteins such as recombinant forms of the costimulatory molecules B7.1 and CD40. "
3.	AIDS-Related Complex (ARC) 08/06/2001 - "Kinetic measurements show that high stability of anchored proteins (t(1/2) approximately 10-20 h, apparent K(d) approximately 1 nM) can be achieved using membranes containing 25 mol% NTA-DTDA, but low levels of bound protein (<200 arc seconds). "

Related Drugs and Biologics

1.	nitrilotriacetic acid ditetradecylamine
2.	Lipids
3.	Chelating Agents
4.	Cancer Vaccines
5.	Proteins (Proteins, Gene)
6.	B7 Antigens
7.	Peptides (Polypeptides)
8.	Nitrilotriacetic Acid
9.	His-His-His-His-His-His ((His)6)