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TH 1177

blocks Ca2+ entry pathway; structure in first source

Also Known As:

TH-1177; TH1177

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - TH 1177: 4

Experts

1.	Cove-Smith, Andrea: 2 articles (01/2020 - 08/2013)
2.	Hendry, Bruce M: 2 articles (01/2020 - 08/2013)
3.	Shattock, Michael J: 2 articles (01/2020 - 08/2013)
4.	Sharpe, Claire C: 1 article (01/2020)
5.	Dutt, Neelanjana: 1 article (08/2013)
6.	McLatchie, Linda M: 1 article (08/2013)
7.	Mulgrew, Christopher J: 1 article (08/2013)
8.	Rudyk, Olena: 1 article (08/2013)
9.	Bolanz, Katrin A: 1 article (02/2011)
10.	Hediger, Matthias A: 1 article (02/2011)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of proliferative glomerulonephritis (GN) including late treatment starting after the initial inflammation has resolved. "
2.	Glomerulonephritis 01/01/2020 - "This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of proliferative glomerulonephritis (GN) including late treatment starting after the initial inflammation has resolved. " 01/01/2020 - "The work supports the use of genetic models to examine the roles of individual cation channels in progressive glomerulonephritis to further define the targets of TH1177."
3.	Prostatic Neoplasms (Prostate Cancer) 02/01/2011 - "The IC(50) value for growth inhibition by blocking endogenous Ca(2+) entry channels in the LNCaP human prostate cancer cell line was 0.44 ± 0.07 μM compared to TH-1177 (50 ± 0.4 μM). " 02/15/2000 - "One of the agents, named TH-1177, was used to treat severe combined immunodeficient mice inoculated with the human prostate cancer line PC-3. " 02/01/2011 - "To develop specific TRPV6 inhibitors, we synthesized molecules based on the lead compound TH-1177, reported to inhibit calcium entry channels in prostate cancer cells in vitro and in vivo. "
4.	Nephritis 08/01/2013 - "Treatment of Thy1 nephritis with TH1177 significantly reduced glomerular injury (P < 0.005) and caused a 49% reduction in glomerular cell number (P < 0.005) compared to the placebo. " 08/01/2013 - "In vivo, rats with Thy1 nephritis were treated with TH1177 or vehicle. "

Related Drugs and Biologics

1.	Cations
2.	Calcium