HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
TOP 008
structure in first source
Also Known As:
TOP-008; bis(ethyl(2R,3R)-3-((S)-3-methyl-1-(4-(3-phenyl)piperazin-1-ylcarbonyl)butylcarbamoyl)oxirane-2-carboxylate)sulfate
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Electrolytes: 16106
Ions: 7857
Anions: 3501
Oxides: 2508
TOP 008: 1
Oxygen Compounds: 12
Oxides: 2508
TOP 008: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperazines: 26
TOP 008: 1
Experts
1.
Eilon, G F
: 1 article (01/2000)
2.
Gu, J
: 1 article (01/2000)
3.
Hara, K
: 1 article (01/2000)
4.
Jacobs, J W
: 1 article (01/2000)
5.
Slater, L M
: 1 article (01/2000)
Related Diseases
1.
Neoplasms (Cancer)
01/01/2000 - "
A final objective of this study was to establish if NCO-700 and TOP-008 achieved cancer cell killing through an apoptotic mechanism.
"
01/01/2000 - "
The anti-proliferative activity of NCO-700 and TOP-008 were tested in a 7 day cell-survival assay utilizing a number of well characterized breast (HS-578T, T47D, MCF-7) and prostate (DU-145, PC-3, LNCaP) cancer cell lines.
"
01/01/2000 - "
These studies indicated that the epoxide-containing piperazines, as exemplified by NCO-700 and TOP-008, were effective anti-cancer agents when tested in vitro and in vivo against human breast and prostate tumors.
"
2.
Breast Neoplasms (Breast Cancer)
01/01/2000 - "
NCO-700 and TOP-008 displayed cytotoxicity to HS-578T human breast cancer cells, with ED(50) values in the 3-6 microM range.
"
01/01/2000 - "
The mechanism of cytotoxicity was shown to be through apoptosis, (a) by confocal microscopy studies revealing nuclear fragmentation, (b) by mitochondrial studies revealing disruption of the mitochondrial membrane and release of the cationic dye, JC-1, into the cytoplasm and (c) by protein immunoblot assays indicating that over a 6 h period, TOP-008 induced a significant accumulation of the pro-apoptotic protein, bak, in the mitochondrial fraction of HS-578T human breast cancer cells, accompanied by activation, at 2.5 h, of caspase-3.
"
3.
Prostatic Neoplasms (Prostate Cancer)
01/01/2000 - "
Two representative compounds, specifically NCO-700, a 4-trimethoxyphenyl-substituted epoxide-piperazine, and TOP-008, a 4-phenylpropenyl-substituted epoxide-piperazine were tested in cytotoxic assays with human breast and prostate cancer cell lines.
"
Related Drugs and Biologics
1.
Caspase 3 (Caspase-3)
2.
Apoptosis Regulatory Proteins
3.
Proteins (Proteins, Gene)
4.
Piperazines
5.
Epoxy Compounds (Epoxides)
6.
Coloring Agents (Dyes)
7.
5,5',6,6'- tetrachloro- 1,1',3,3'- tetraethylbenzimidazolocarbocyanine
8.
NCO 700
9.
Piperazine
10.
A 7 (A-7)