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OPC 29030
structure in second source; inhibitor of 12(S)-hydroxyeicosatetraenoic acid (12-HETE) synthesis; anti-platelet agent;
Also Known As:
(S)-(+)-6-(3-(1-o-tolylimidazol-2-yl)sulfinylpropoxy)-3,4-dihydro-2(1H)-quinolinone; OPC-29030
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
OPC 29030: 2
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Quinolones: 2938
OPC 29030: 2
Inorganic Chemicals: 9
Sulfur Compounds: 278
OPC 29030: 2
Organic Chemicals: 133
Sulfur Compounds: 278
OPC 29030: 2
Experts
1.
Kawasaki, K
: 1 article (11/2000)
2.
Komori, K
: 1 article (11/2000)
3.
Okazaki, J
: 1 article (11/2000)
4.
Ozeki, Y
: 1 article (11/2000)
5.
Sugimachi, K
: 1 article (11/2000)
Related Diseases
1.
Hyperplasia
11/01/2000 - "
These results demonstrate the efficacy of OPC-29030 in reducing the degree of intimal hyperplasia under PR conditions, but not under hyperlipidemic conditions.
"
11/01/2000 - "
However, in the HL group, the intimal hyperplasia in both the OPC-29030 and control groups showed a remarkable degree of intimal hyperplasia.
"
11/01/2000 - "
The efficacy of OPC-29030, a newly developed inhibitor of 12(S)-hydroxyeicosatetraenoic acid (12-HETE) production, was evaluated on intimal hyperplasia of experimental autologous vein grafts in a distal poor-runoff model and a hyperlipidemic model in rabbits.
"
11/01/2000 - "
In the in vivo study in the PR group, the intimal hyperplasia and the plasma 12-HETE levels in the OPC-29030 group were significantly inhibited, compared with those of the control group.
"
11/01/2000 - "
The mechanism of reducing the intimal hyperplasia may be that OPC-29030 inhibited 12-HETE production, which did not inhibit proliferation while inhibiting migration of the smooth muscle cell.
"
2.
Coronary Thrombosis
12/22/1998 - "
OPC-29030 reduced intraplatelet 12-HETE levels, resulting in the inhibition of coronary thrombosis in vivo in dogs.
"
Related Drugs and Biologics
1.
Acids
2.
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid