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laminin 9

MW 740 kDa

Also Known As:

alpha4beta2gamma1-laminin; laminin-9

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Black, Keith L: 3 articles (01/2006 - 08/2004)
2.	Khazenzon, Natalya M: 3 articles (01/2006 - 08/2004)
3.	Ljubimova, Julia Y: 3 articles (01/2006 - 08/2004)
4.	Fujita, Manabu: 2 articles (01/2006 - 01/2005)
5.	Ljubimov, Alexander V: 2 articles (01/2006 - 01/2005)
6.	Sasaki, Takako: 2 articles (01/2005 - 08/2004)
7.	Sekiguchi, Kiyotoshi: 2 articles (01/2005 - 08/2004)
8.	Bose, Shikha: 1 article (01/2005)
9.	Carter, William G: 1 article (01/2005)
10.	Das, Asha: 1 article (08/2004)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2001 - "GBMs that overexpressed laminin-8 had a shorter mean time to tumor recurrence (4.3 months) than GBMs with overexpression of laminin-9 (9.7 months, P = 0.0007). " 01/01/2006 - "Here we show that during progression of glial tumors laminin-9 (alpha4beta2gamma1) is switched to laminin-8 (alpha4beta1gamma1), which is dramatically increased in glial brain tumors. " 07/15/2001 - "Importantly, an alpha4 chain-containing laminin isoform, laminin-8 (alpha4beta1gamma1), was expressed mainly in blood vessel walls of GBMs and histologically normal tissues adjacent to GBMs, whereas another alpha4 chain-containing laminin isoform, laminin-9 (alpha4beta2gamma1), was expressed mainly in blood vessel walls of low-grade tumors and normal brain. "
2.	Ductal Carcinoma 01/01/2005 - "Forty-five clinical samples of breast tissues including normal breast, ductal carcinomas in situ, invasive ductal carcinomas, and their metastases to the brain were compared using Western blot analysis and immunohistochemistry for various chains of laminin, in particular laminin-8 and laminin-9. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2005 - "At the same time, the expression of laminin beta2 chain (a constituent of laminin-9) was mostly seen in normal breast and carcinomas in situ but not in invasive carcinomas or metastases. " 01/01/2005 - "Forty-five clinical samples of breast tissues including normal breast, ductal carcinomas in situ, invasive ductal carcinomas, and their metastases to the brain were compared using Western blot analysis and immunohistochemistry for various chains of laminin, in particular laminin-8 and laminin-9. "
4.	Meningioma (Meningiomas) 08/01/2004 - "Using immunohistochemistry and Western blot analysis, the authors confirmed high levels of laminin-8 expression in approximately 75% of the GBM cases examined and in their adjacent tissues, whereas astrocytomas of lower grades expressed for the most part a different isoform, laminin-9, which also was found in low amounts in normal brain tissue and benign meningiomas. "
5.	Glioma (Gliomas) 01/01/2005 - "We previously documented a switch in the expression of vascular laminins containing the alpha4 chain from predominantly laminin-9 (alpha4beta2gamma1) to predominantly laminin-8 (alpha4beta1gamma1) during progression of human brain gliomas to high-grade glioblastoma multiforme. "

Related Drugs and Biologics

1.	laminin 8
2.	Protein Isoforms (Isoforms)
3.	Laminin (Merosin)
4.	laminin 10
5.	laminin beta2 (S-laminin)