Streptococcus intermedius intermedilysin protein

a cytotoxin specific for human cells secreted by Streptococcus intermedius UNS46, isolated from a human liver abscess; purified toxin has major and minor bands of 54 and 53 kDa, respectively; has been sequenced

Also Known As:

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nagamune, Hideaki: 4 articles (01/2011 - 09/2004)
2.	Qin, Xuebin: 3 articles (01/2020 - 09/2010)
3.	Kourai, Hiroki: 3 articles (01/2005 - 09/2004)
4.	Ohkura, Kazuto: 3 articles (01/2005 - 09/2004)
5.	Liu, Fengming: 2 articles (01/2020 - 04/2014)
6.	Zhang, Jinyan: 2 articles (01/2020 - 09/2010)
7.	Hirota, Katsuhiko: 2 articles (01/2011 - 01/2005)
8.	Miyake, Yoichiro: 2 articles (01/2011 - 01/2005)
9.	Chen, Jiayi: 1 article (01/2020)
10.	Dai, Shen: 1 article (01/2020)

Related Diseases

1.	Hemolysis 01/01/2000 - "Quantitative studies on the haemolysis indicated that intermedilysin was the factor involved. " 09/02/2010 - "We recently generated a unique intravascular hemolysis mouse model in which the membrane toxin, intermedilysin (ILY), exclusively lyses the erythrocytes of transgenically expressing human CD59 mice (ThCD59(RBC)), thereby inducing ILY-dose-dependent massive hemolysis. " 04/01/2009 - "The demonstration that a peptide modeled on the CD59-binding site inhibits intermedilysin-mediated haemolysis leads us to suggest that such peptides might be useful in treating infections caused by intermedilysin-producing bacteria." 01/01/2000 - "Moreover, a human-specific hemolysis assay and Western blotting with intermedilysin-specific antibodies clearly demonstrated that the intermedilysin production level in isolates from deep-seated infections, such as brain and liver abscesses, is higher (6.2- to 10.2-fold, respectively) than in strains from normal habitats, such as dental plaque, or from peripheral infection sites. " 02/01/2010 - "The tests performed included Lancefield grouping; tests for hemolysis; tests for the production of hyaluronidase, chondroitin sulfatase, DNase, proteases, and hydrogen peroxide; and PCR for the detection of the intermedilysin gene (ily). "
2.	Carcinoma (Carcinomatosis) 04/25/2014 - "In this study, we used non-small lung carcinoma cells to characterize the mechanism of a novel CD59 inhibitor: the 114-amino acid recombinant form of the 4th domain of intermedilysin (rILYd4), a pore forming toxin secreted by Streptococcus intermedius. "
3.	Liver Abscess 08/01/1996 - "A novel cytotoxin (intermedilysin) specific for human cells was identified as a cytolytic factor of Streptococcus intermedius UNS46 isolated from a human liver abscess. " 08/01/1996 - "Intermedilysin, a novel cytotoxin specific for human cells secreted by Streptococcus intermedius UNS46 isolated from a human liver abscess." 01/07/2011 - "Intermedilysin (ILY) is a cholesterol-dependent cytolysin produced by Streptococcus intermedius, which is associated with human brain and liver abscesses. " 01/01/2000 - "Moreover, a human-specific hemolysis assay and Western blotting with intermedilysin-specific antibodies clearly demonstrated that the intermedilysin production level in isolates from deep-seated infections, such as brain and liver abscesses, is higher (6.2- to 10.2-fold, respectively) than in strains from normal habitats, such as dental plaque, or from peripheral infection sites. "
4.	Neoplasms (Cancer) 09/01/2004 - "A cell membrane modification technique using domain 4 of intermedilysin for immunotherapy against cancer." 09/01/2004 - "Structural analysis of human specific cytolysin intermedilysin aiming application to cancer immunotherapy."
5.	Infections 01/01/2000 - "From these results, intermedilysin is likely to be the pathogenic or triggering factor of significance in inducing deep-seated infections with S. " 01/01/2000 - "Distribution of the intermedilysin gene among the anginosus group streptococci and correlation between intermedilysin production and deep-seated infection with Streptococcus intermedius." 01/01/2000 - "The distribution of intermedilysin, a human-specific cytolysin, among the anginosus group streptococci and the correlation of toxin production and infection by Streptococcus intermedius were investigated. " 04/01/2009 - "The demonstration that a peptide modeled on the CD59-binding site inhibits intermedilysin-mediated haemolysis leads us to suggest that such peptides might be useful in treating infections caused by intermedilysin-producing bacteria." 01/01/2000 - "Moreover, a human-specific hemolysis assay and Western blotting with intermedilysin-specific antibodies clearly demonstrated that the intermedilysin production level in isolates from deep-seated infections, such as brain and liver abscesses, is higher (6.2- to 10.2-fold, respectively) than in strains from normal habitats, such as dental plaque, or from peripheral infection sites. "

Related Drugs and Biologics

1.	Acids
2.	Perforin
3.	Calcineurin
4.	Sulfatases
5.	Peptides (Polypeptides)
6.	Peptide Hydrolases (Proteases)
7.	Hydrogen Peroxide (Hydroperoxide)
8.	Hyaluronoglucosaminidase (Hyaluronidase)
9.	Deoxyribonucleases (DNase)
10.	Cytotoxins (Cytolysins)

Related Therapies and Procedures

1.	Immunotherapy