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4-oxo-2-nonenal

reacts with 2'-deoxyguanosine; a product of lipid peroxidation; structure in first source

Also Known As:

4-oxonon-2-enal

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - 4-oxo-2-nonenal: 6

Experts

1.	Amarnath, Venkataraman: 2 articles (12/2019 - 10/2015)
2.	Borja, Mark S: 1 article (12/2019)
3.	Davidson, W Sean: 1 article (12/2019)
4.	Davies, Sean S: 1 article (12/2019)
5.	Linton, MacRae F: 1 article (12/2019)
6.	May-Zhang, Linda S: 1 article (12/2019)
7.	Melchior, John T: 1 article (12/2019)
8.	Morris, Jamie: 1 article (12/2019)
9.	Pleasent, Tiffany: 1 article (12/2019)
10.	Song, Wenliang: 1 article (12/2019)

Related Diseases

1.	Neuroblastoma 08/01/2005 - "4-Hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) have been shown here to be toxic to human neuroblastoma cells in culture at low micromolar concentrations. " 01/13/2006 - "To identify an oxidized lipid that induces p53 phosphorylation, we conducted a screening of lipid peroxidation products in human neuroblastoma SH-SY5Y cells and identified 4-oxo-2-nonenal (ONE), a recently identified aldehyde originating from the peroxidation of omega6 polyunsaturated fatty acids, as a potential inducer of the p53 phosphorylation. "
2.	Neoplasms (Cancer) 01/01/2010 - "These LPO products such as 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) can contribute to the development of cardiovascular and neurodegenerative diseases and cancer. " 10/19/2015 - "4-Oxo-2-nonenal (ONE), a product of cellular lipid oxidation, reacts nonspecifically with the lysine residues of proteins and is generated in increased amounts during degenerative diseases and cancer. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2010 - "These LPO products such as 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) can contribute to the development of cardiovascular and neurodegenerative diseases and cancer. "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2017 - "We also examined CBR1 inhibition by oleic acid in cellular levels: The fatty acid effectively inhibited CBR1-mediated 4-oxo-2-nonenal metabolism in colon cancer DLD1 cells and increased sensitivity to doxorubicin in the drug-resistant gastric cancer MKN45 cells that highly express CBR1. "
5.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 12/13/2019 - "Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia."

Related Drugs and Biologics

1.	Lipids
2.	4-hydroxy-2-nonenal (4-hydroxynonenal)
3.	Oleic Acid (Oleate)
4.	Proteins (Proteins, Gene)
5.	Lysine (L-Lysine)
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Doxorubicin (Adriamycin)
9.	Aldehydes