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benzyloxycarbonyl- leucyl- glutamyl- histidyl- aspartic acid fluoromethyl ketone

caspase-9 inhibitor

Also Known As:

Z-LEHD-fmk

Networked: 23 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone: 23

Experts

1.	Casablanca, Yovanni: 1 article (01/2021)
2.	Maxwell, G Larry: 1 article (01/2021)
3.	McGlorthan, Latoya: 1 article (01/2021)
4.	Paucarmayta, Ana: 1 article (01/2021)
5.	Syed, Viqar: 1 article (01/2021)
6.	Hao, Hong: 1 article (01/2019)
7.	Jiang, Bimei: 1 article (01/2019)
8.	Li, Yuanbin: 1 article (01/2019)
9.	Liang, Pengfei: 1 article (01/2019)
10.	Liu, Zhenguo: 1 article (01/2019)

Related Diseases

1.	Infarction (Infarctions) 09/01/2002 - "Administration of the caspase-9 inhibitor, Z-LEHD-FMK, to the experimental group (n = 12) reduced total infarction volume by 49% (p < 0.05) and improved neurological outcome by 63% (p < 0.01) as compared to the control group (n = 12). "
2.	Spinal Cord Injuries (Spinal Cord Injury) 03/01/2005 - "Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury." 03/01/2005 - "The aim of this study was to evaluate the neuroprotective effect of the caspase-9 inhibitor, z-LEHD-fmk, in a rat model of spinal cord trauma. " 07/01/2013 - "We investigated the individual and combined effects of magnesium sulphate, which is an N-Methyl-D aspartate receptor antagonist (NMDA), and z-LEHD-FMK, which is a caspase 9 inhibitor, on the genesis of secondary injury in a rat spinal cord injury model. "
3.	Carcinoma (Carcinomatosis) 11/01/2002 - "Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes and HCT116 human colon carcinoma cells behave like Type II cells because TRAIL-induced apoptosis can be blocked by the caspase 9 inhibitor, Z-LEHD-FMK. " 04/01/2005 - "Selective inhibitors of caspase-2 (Z-VDVAD-FMK), caspase-9 (Z-LEHD-FMK), and caspase-3 (Z-DEVD-FMK) protected both leukemia and carcinoma cells from LfcinB-induced apoptosis. "
4.	Breast Neoplasms (Breast Cancer) 04/21/2006 - "Immunoblot studies further illustrated that although EAE-PS downregulated the anti-apoptotic Bcl-2/Bcl-X(L) expression in breast cancer cells, the induced apoptosis could not be prevented by the caspase-9 inhibitor (Z-LEHD-FMK). "
5.	Infections 12/01/2015 - "tenella infection rates, DNA injury rates, and apoptosis rates in groups treated with and without the caspase-9 inhibitor Z-LEHD-FMK. " 09/02/2004 - "Selective blockage of caspase-9 activities by Z-LEHD-FMK completely attenuated DAC-induced enhancement of apoptosis mediated by Ad-p53 infection, and ectopic overexpression of procaspase-9 sensitized cells to Ad-p53-induced apoptosis in p53-null cells. " 10/01/2015 - "Interestingly, caspase-2 and -8 were not cleaved or activated during the infection, whilst a selective inhibitor of caspase-9, Z-LEHD-FMK, blocked the cleavage of caspase-3 and -7, indicating that only the mitochondria-mediated intrinsic apoptotic pathway was activated in EV71-infected astrocytes. " 10/10/2007 - "To determine the caspase activation pathways involved in EAV-induced apoptosis, target cells were treated with peptide inhibitors of apoptosis Z-VAD-FMK (pan-caspase inhibitor), Z-IETD-FMK (caspase-8-specific inhibitor) or Z-LEHD-FMK (caspase-9-specific inhibitor) 4 h prior to infection with the EAV T1329 Canadian isolate. "

Related Drugs and Biologics

1.	Caspase 9
2.	Neuroprotective Agents
3.	Caspase 3 (Caspase-3)
4.	benzyloxycarbonyl- isoleucyl- glutamyl- threonyl- aspartic acid fluoromethyl ketone
5.	benzoylcarbonyl- aspartyl- glutamyl- valyl- aspartyl- fluoromethyl ketone
6.	Caspase 8 (Caspase-8)
7.	Caspases
8.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
9.	Caspase Inhibitors
10.	Caspase 2