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benzyloxycarbonyl- isoleucyl- glutamyl- threonyl- aspartic acid fluoromethyl ketone

Also Known As:

Z-IETD-fmk

Networked: 19 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone: 19

Experts

1.	Ding, Li: 1 article (05/2022)
2.	Dong, Xin-Hang: 1 article (05/2022)
3.	Li, Hao-Ran: 1 article (05/2022)
4.	Liu, Meng-Yu: 1 article (05/2022)
5.	Liu, Yi-Fang: 1 article (05/2022)
6.	Long, Xiao: 1 article (05/2022)
7.	Pan, De-Li: 1 article (05/2022)
8.	Si, Lou-Bin: 1 article (05/2022)
9.	Wang, Xiao-Jun: 1 article (05/2022)
10.	Zhang, Ming-Zi: 1 article (05/2022)

Related Diseases

1.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 07/01/2020 - "The Morris water maze and rotarod test confirmed that Z-IETD-FMK significantly improved spatial learning and memory abilities and motor coordination at 21-27 days after subarachnoid hemorrhage. " 07/01/2020 - "Z-IETD-FMK significantly improved neurological deficits and reduced brain water content 24 hours after subarachnoid hemorrhage. " 07/01/2020 - "Z-IETD-FMK (0.5, 1, 2 mg/kg; an inhibitor of caspase-8) was delivered via intravenous (tail vein) injection immediately after subarachnoid hemorrhage. "
2.	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 11/01/2017 - "In this study, we investigated the mechanism by which CD40 mediates apoptosis in a follicular lymphoma cell line, HF4.9. We show here that CD40-induced apoptosis was dependent on caspase-8 activation because caspase-8 specific inhibitor, Z-IETD-FMK completely prevented apoptosis. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2014 - "Conversely, caspase 8 inhibitor Z-IETD-FMK blocked the apoptotic ability of EP to cleave PARP and an increase of sub G1 population in DU 145 prostate cancer cells. " 01/01/2013 - "We further found that lupulone derivatives induced caspase-dependent apoptosis that is associated with activation of caspases 8, 9, and 3. Furthermore, caspase 8 inhibitor Z-IETD-fmk reduced cell death induced by lupulone derivatives, suggesting that apoptosis is mediated by caspase 8. Finally, we found that lupulone and its synthetic derivatives also increased formation of LC3II suggesting that autophagy is also implicated in prostate cancer cell death. "
4.	Neoplasms (Cancer) 07/01/2008 - "The pan-caspase inhibitor Z-VAD-FMK and caspase-8 inhibitor Z-IETD-FMK, but not the caspase-9 inhibitor Z-IEHD-FMK, protected tumor cells from MV-CEA/GA-induced PARP activation, indicating that apoptosis in combination-treated cells occurs mainly via the extrinsic caspase pathway. " 01/01/2021 - "Pretreatment of cancer cells with a caspase-8 inhibitor (z-IETD-fmk) or caspase-9 inhibitor (Z-LEHD-fmk) significantly attenuated progesterone and calcitriol induced caspase-8 and caspase-9 expression, respectively. "
5.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 08/15/2004 - "Viability loss and decrease in GSH contents in small cell lung cancer (SCLC) cells treated with MG132 was attenuated by caspase inhibitors (z-IETD.fmk, z-LEHD.fmk and z-DQMD.fmk). "

Related Drugs and Biologics

1.	Caspase 8 (Caspase-8)
2.	Caspase 9
3.	benzyloxycarbonyl- leucyl- glutamyl- histidyl- aspartic acid fluoromethyl ketone
4.	Caspases
5.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
6.	Caspase Inhibitors
7.	Caspase 3 (Caspase-3)
8.	Cytochromes c (Cytochrome c)
9.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
10.	Fas Ligand Protein (Fas Ligand)

Related Therapies and Procedures

1.	Injections
2.	Cannula