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LXR 1035

a synthetic analog of oleoyl lysophosphatidic acid; inhibits leukocyte-endothelium interaction via inhibition of cell adhesion molecules

Also Known As:

LXR-1035

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Lysophospholipids: 554
        LXR 1035: 2

Experts

1.	Dhallu, Manjeet S: 1 article (11/2006)
2.	Malhotra, Samit: 1 article (11/2006)
3.	Mammis, Antonios: 1 article (11/2006)
4.	Ocava, Lenore C: 1 article (11/2006)
5.	Rosenbaum, Daniel M: 1 article (11/2006)
6.	Rosenbaum, Pearl S: 1 article (11/2006)
7.	Savitz, Sean I: 1 article (11/2006)
8.	Lefer, A M: 1 article (01/2000)
9.	Pruefer, D: 1 article (01/2000)
10.	Scalia, R: 1 article (01/2000)

Related Diseases

1.	Ischemia 11/06/2006 - "Animals pretreated with LXR-1035 had dose-dependent, significant reductions in histopathologic damage and significant improvement in functional deficits compared with corresponding vehicle-controls, after 45 and 60 min of ischemia. "
2.	Reperfusion Injury 11/06/2006 - "We examined the expression of EDG receptors in a model of retinal ischemia-reperfusion injury and also tested LXR-1035, a novel analogue of LPA, in the rat following global retinal ischemic injury. "
3.	Hemorrhage 01/01/2000 - "However, superfusion of the rat mesentery with LXR-1035 markedly attenuated the leukocyte-endothelium interaction occurring after hemorrhage and reinfusion by 75+/-12%. " 01/01/2000 - "Immunohistochemical localization of P-selectin expression on mesenteric venular endothelium was significantly increased after exposure to L-NAME and after hemorrhage-reinfusion, which was significantly attenuated by LXR-1035 (P<0.05). "

Related Drugs and Biologics

1.	NG-Nitroarginine Methyl Ester (L-NAME)
2.	P-Selectin
3.	Retinaldehyde (Retinal)
4.	Sphingosine-1-Phosphate Receptors