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ZK 164015

structure in first source

Also Known As:

ZK 164,015; ZK-164,015; ZK-164015; ZK164,015

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - ZK 164015: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - ZK 164015: 2

Experts

1.	Caunt, Christopher J: 1 article (01/2009)
2.	Maru, Benit S: 1 article (01/2009)
3.	McArdle, Craig A: 1 article (01/2009)
4.	Norman, Michael R: 1 article (01/2009)
5.	Rivers, Caroline: 1 article (01/2009)
6.	Tobias, Jonathan H: 1 article (01/2009)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

04/01/1996 - "The sulfone (ZK 164,015) completely abolished the effect of a standard dose of estrone at a daily dose of 7 mg/kg. This compound strongly inhibited the growth of hormone-sensitive human MCF-7 breast cancer cells with an IC50-value close to 1 nM. Similar activity was found for the steroidal sulfoxide ICI 182,780. "
01/01/2009 - "Osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells were transfected with a human ERalpha-GFP fusion protein, and treated with ER agonists (17beta-estradiol, and dienestrol), antagonists (ICI 182,780 and ZK 164015) and SERMs (tamoxifen, raloxifene, 4-hydroxytamoxifen (4-HT) and hexestrol). "

Related Drugs and Biologics

1.	Fulvestrant (Faslodex)
2.	Estrogen Receptor alpha
3.	Raloxifene Hydrochloride (Evista)
4.	Selective Estrogen Receptor Modulators (SERM)
5.	Tamoxifen
6.	Sulfones
7.	Proteins (Proteins, Gene)
8.	Hormones (Hormone)
9.	Hexestrol
10.	Estrone