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HI 443

structure in first source

Also Known As:

HI-443; N'-(2-(2-thiophene)ethyl)-N'-(2-(5-bromopyridyl))thiourea; PHI 443; PHI-443; PHI443

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - HI 443: 3
Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - HI 443: 3
- Sulfur Compounds: 278
  - Thiourea: 362
    - HI 443: 3

Experts

1.	Uckun, Fatih M: 3 articles (03/2012 - 12/2004)
2.	D'Cruz, Osmond J: 2 articles (03/2012 - 12/2004)
3.	Qazi, Sanjive: 1 article (03/2012)
4.	Yiv, Seang: 1 article (03/2012)
5.	Erbeck, Douglas: 1 article (01/2007)
6.	Tibbles, Heather E: 1 article (01/2007)
7.	Venkatachalam, Taracad K: 1 article (01/2007)
8.	Samuel, Peter: 1 article (12/2004)

Related Diseases

1.

Acquired Immunodeficiency Syndrome (AIDS)

01/01/2007 - "HI-443 was very well tolerated in CD-1 mice and Lewis rats without any detectable toxicity at single parenteral bolus dose levels as high as 80 mg/kg. Intraperitoneally administered HI-443 exhibited anti-HIV activity in the Hu-PBL-SCID mouse surrogate model for hunnan AIDS at a non-toxic daily dose level of 10-20 mg/kg. These preclinical research studies provide the basis for future preclinical studies and clinical development of HI-443 as a new NNRTI candidate."
03/01/2012 - "Intravaginally administered HI-443 prevented vaginal transmission of a drug-resistant clinical HIV-1 isolate in the surrogate Hu-PBL-SCID mouse model of AIDS. "
12/01/2004 - "PHI-443 completely prevented the vaginal transmission of a genotypically and phenotypically drug-resistant HIV-1 isolate in the humanized severe combined immunodeficient (Hu-SCID) mouse model of sexually transmitted AIDS. "