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CLIK 148

structure in first source

Also Known As:

CLIK148; N-(L-3-trans-(2-pyridin-2-yl-ethylcarbamoyl)-oxirane-2-carbonyl)-L-Phe-dimethylamide

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - CLIK 148: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - CLIK 148: 4

Experts

1.	Katunuma, Nobuhiko: 2 articles (06/2014 - 11/2009)
2.	Jakoš, Tanja: 1 article (09/2020)
3.	Kos, Janko: 1 article (09/2020)
4.	Pečar Fonović, Urša: 1 article (09/2020)
5.	Pišlar, Anja: 1 article (09/2020)
6.	Švajger, Urban: 1 article (09/2020)
7.	Gu, Wei-Wei: 1 article (06/2014)
8.	Ishidoh, Kazumi: 1 article (06/2014)
9.	Li, Zhong-Sheng: 1 article (06/2014)
10.	Luo, Yu: 1 article (06/2014)

Related Diseases

1.	Infarction (Infarctions) 06/01/2014 - "In the rat models of pMCAO, CA-074Me or Clik148, a selective inhibitor of cathepsin B or cathepsin L, reduced the infarct volume, improved the neurological deficits and increased the MAP2 and GFAP levels. "
2.	Infections 08/01/2001 - "Taken together, these findings suggest that treatment of host mice with CLIK148 affects the processing of SLA in APC, resulting in the potentiation of T (h) 2-type immune responses and thus leading to exacerbation of the infection. " 11/25/2009 - "The CA-074Me treatment of NIH3T3 cells inhibited cathepsin L activity, and a cathepsin L specific inhibitor, CLIK148, attenuated the Eco-MLV vector infection. " 11/25/2009 - "The CA-074Me treatment inhibited the Eco-MLV infection in human cells expressing the exogenous mouse ecotropic receptor and endogenous cathepsins B and L, but the CLIK148 treatment did not, showing that only the cathepsin L suppression by CLIK148 is not enough to prevent the Eco-MLV infection in cells expressing both of cathepsins B and L, and CA-074Me inhibits the Eco-MLV infection by suppressing both of cathepsins B and L. " 08/01/2001 - "Interestingly, treatment of BALB/c mice with CLIK148 exacerbated the infection by enhancing the development of SLA-specific T (h) 2-type response such as production of IL-4 and generation of T (h) 2-dependent specific IgE/IgG1 antibodies. "
3.	Neoplasms (Cancer) 09/01/2020 - "During this transition to MDSCs, the overall levels of cysteine cathepsins increased, with the largest responses for cathepsins L and X. We used small-molecule inhibitors of cathepsins L and X (i.e., CLIK-148, Z9, respectively) to investigate their functional impact on tumor cells and immune cells in this co-culture system. "
4.	Ischemia 06/01/2014 - "CA-074Me or Clik148 blocked the pMCAO-induced release of cathepsin B or L from the lysosomes into the cytoplasm and activation of caspase-3 in ischemic astrocytes at 12 h after ischemia. "

Related Drugs and Biologics

1.	Cathepsin L
2.	CA 074 methyl ester
3.	Cathepsin B
4.	Cathepsins
5.	Caspase 3 (Caspase-3)
6.	Interleukin-4 (Interleukin 4)
7.	Immunoglobulin G (IgG)
8.	Immunoglobulin E (IgE)
9.	Cysteine (L-Cysteine)
10.	Antibodies