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GW420867X

structure in first source

Also Known As:

(S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydro-2H-quinoxalinecarboxylic acid isopropylester; GW 420867X

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - GW420867X: 2

Experts

1.	Cass, L: 1 article (11/2000)
2.	Prince, W: 1 article (11/2000)
3.	Segal, M: 1 article (11/2000)
4.	Thomas, S: 1 article (11/2000)
5.	Balzarini, J: 1 article (04/2000)
6.	Burt, V: 1 article (04/2000)
7.	Carbonez, A: 1 article (04/2000)
8.	De Clercq, E: 1 article (04/2000)
9.	Kleim, J P: 1 article (04/2000)

Related Diseases

1.	Infections 04/10/2000 - "Our data suggest that combinations of GW420867X with 3TC, ABC, and NNRTIs (e.g., efavirenz) would be worth pursuing as therapeutic modalities against HIV-1 infections." 04/10/2000 - "Whereas the antiviral efficacy of combinations of GW420867X with the NRTIs lamivudine (3TC) and abacavir (ABC) proved additive when administered to HIV-1-infected cells in a short-term (4-day) infection experiment, combination of GW420867X with the NRTIs 3TC and ABC resulted in a marked delay of virus breakthrough compared with the single drugs alone in a long-term (2-month) infection experiment. "
2.	HIV Infections (HIV Infection) 11/27/2000 - "This would suggest that GW420867X is a promising drug for the treatment of HIV infection within the brain." 11/27/2000 - "(S)-2-ethyl-7-fluoro-3-oxo-3, 4-dihydro-2H-quinoxaline-carboxylic acid isopropylester (GW420867X) inhibits HIV-1 reverse transcriptase and could be used for the treatment of HIV infection. "

Related Drugs and Biologics

1.	Lamivudine (Epivir)
2.	Antiviral Agents (Antivirals)
3.	abacavir (Ziagen)
4.	Acids
5.	Human immunodeficiency virus 1 reverse transcriptase
6.	efavirenz (Sustiva)