HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1,5- bis- (4- ((3- carbamimidoyl- benzenesulfonylamino)- methyl)- phenoxy)- pentane

structure in first source

Also Known As:

AMG 126737; AMG-126737

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Pentanes
        1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - 1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane: 1

Related Diseases

1.	Respiratory Hypersensitivity 12/15/1999 - "The in vivo activity of AMG-126737 was confirmed in a sheep model of allergen-induced airway responses, where the compound inhibited early and late phase bronchoconstriction responses and the development of airway hyperresponsiveness. " 12/15/1999 - "Intratracheal administration of AMG-126737 inhibited the development of airway hyperresponsiveness in allergen-challenged guinea pigs with an ED50 of 0.015 mg/kg. In addition, the compound exhibited oral activity in the guinea pig model. "
2.	Asthma (Bronchial Asthma) 12/15/1999 - "These results support the proposed role of tryptase in the pathology of asthma and suggest that AMG-126737 has potential therapeutic utility in this pulmonary disorder."

Related Drugs and Biologics

1.	Tryptases (Tryptase)
2.	Allergens